Microbial immune suppression mediated by direct engagement of inhibitory Fc receptor

Claudia Monari, Thomas R. Kozel, Francesca Paganelli, Eva Pericolini, Stefano Perito, Francesco Bistoni, Arturo Casadevall, Anna Vecchiarelli

Research output: Contribution to journalArticlepeer-review

Abstract

A microbial polysaccharide (glucuronoxylomannan (GXM)) exerts potent immunosuppression by direct engagement to immunoinhibitory receptor FcγRIIB. Activation of FcγRIIB by GXM leads to the recruitment and phosphorylation of SHIP that prevents IκBα activation. The FcγRIIB blockade inhibits GXM-imduced IL-10 production and induces TNF-α secretion. GXM qnenches LPS-induced TNF-α release via FcγRIIB. The addition of mAb to GXM reverses GXM-induced immunosappression by shifting recognition from FcγRIIB to FcγRIIA. These findings indicate a novel mechanism by which microbial products can impair immune function through direct stimulation of an inhibitory receptor. Furthermore, our observations provide a new mechanism for the ability of specific Ab to reverse the immune inhibitory effects of certain microbial products.

Original languageEnglish (US)
Pages (from-to)6842-6851
Number of pages10
JournalJournal of Immunology
Volume177
Issue number10
DOIs
StatePublished - Nov 15 2006
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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