TY - JOUR
T1 - Microbes, microbiota, and colon cancer
AU - Sears, Cynthia L.
AU - Garrett, Wendy S.
N1 - Funding Information:
We thank current and former members of the Sears and Garrett labs. C.L.S. also thanks Drew Pardoll, Ken Kinzler, Bert Vogelstein, and members of their groups for helpful discussions over time; W.S.G. also thanks Aleksandar D. Kostic, Andrew T. Chan, and Curtis Huttenhower for thoughtful discussions. C.L.S. acknowledges the following funding sources: NIH (R01CA151393, R21CA170492, R01CA151325, R01CA179440) and the Merieux Institute. W.S.G. acknowledges the following funding sources: NIH (R01CA154426 and K08AI078942), a Burroughs Wellcome Career in Medical Sciences Award, a Searle Scholars Award, and a Cancer Research Institute Investigator Award.
PY - 2014/3/12
Y1 - 2014/3/12
N2 - Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human colon is also an anatomical location with the largest number of microbes. It is natural, therefore, to anticipate a role for microbes, particularly bacteria, in colorectal carcinogenesis. The increasing accessibility of microbial meta'omics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. In this review, we will discuss recent insights into contributions of the microbiota to CRC and explore conceptual frameworks for evaluating the role of microbes in cancer causation. We also highlight new findings on candidate CRC-potentiating species and current knowledge gaps. Finally, we explore the roles of microbial metabolism as it relates to bile acids, xenobiotics, and diet in the etiology and therapeutics of CRC.
AB - Colorectal cancer (CRC) presents a considerable disease burden worldwide. The human colon is also an anatomical location with the largest number of microbes. It is natural, therefore, to anticipate a role for microbes, particularly bacteria, in colorectal carcinogenesis. The increasing accessibility of microbial meta'omics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. In this review, we will discuss recent insights into contributions of the microbiota to CRC and explore conceptual frameworks for evaluating the role of microbes in cancer causation. We also highlight new findings on candidate CRC-potentiating species and current knowledge gaps. Finally, we explore the roles of microbial metabolism as it relates to bile acids, xenobiotics, and diet in the etiology and therapeutics of CRC.
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U2 - 10.1016/j.chom.2014.02.007
DO - 10.1016/j.chom.2014.02.007
M3 - Review article
C2 - 24629338
AN - SCOPUS:84896078883
SN - 1931-3128
VL - 15
SP - 317
EP - 328
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 3
ER -