Microarrays have rapidly become popular for high-throughput functional genomic studies. For example, strategies to identify single nucleotide polymorphisms and studies of differential mRNA expression make use of oligonucleotide or DNA microarrays. More recently, protein-based arrays using immobilized fusion proteins or antibodies have been developed. The latest in these innovations is the development of microarrays containing live cells that express a cDNA of interest. These arrays are an excellent complement to DNA and protein 'chips' for high-throughput proteomic studies.
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