Microarrays and toxicology: The advent of toxicogenomics

Emile F. Nuwaysir, Michael Bittner, Jeffrey Trent, J. Carl Barrett, Cynthia A. Afshari

Research output: Contribution to journalReview article

Abstract

The availability of genome-scale DNA sequence information and reagents has radically altered life-science research. This revolution has led to the development of a new scientific subdiscipline derived from a combination of the fields of toxicology and genomics. This subdiscipline, termed toxicogenomics, is concerned with the identification of potential human and environmental toxicants, and their putative mechanisms of action, through the use of genomics resources. One such resource is DNA microarrays or 'chips,' which allow the monitoring of the expression levels of thousands of genes simultaneously. Here we propose a general method by which gene expression, as measured by cDNA microarrays, can be used as a highly sensitive and informative marker for toxicity. Our purpose is to acquaint the reader with the development and current state of microarray technology and to present our view of the usefulness of microarrays to the field of toxicology.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalMolecular Carcinogenesis
Volume24
Issue number3
DOIs
StatePublished - Apr 20 1999

Keywords

  • Animal bioassay
  • Gene expression
  • Toxicology

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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