Microarray techniques in pathology: Tool or toy?

A. M. Snijders; G. A. Meijer; R. H. Brakenhoff; A. J.C. Van den Brule; P. J. Van Diest

doi:10.1136/mp.53.6.289

Microarray techniques in pathology: Tool or toy?

A. M. Snijders, G. A. Meijer, R. H. Brakenhoff, A. J.C. Van den Brule, P. J. Van Diest

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

Original language	English (US)
Pages (from-to)	289-294
Number of pages	6
Journal	Journal of Clinical Pathology - Molecular Pathology
Volume	53
Issue number	6
DOIs	https://doi.org/10.1136/mp.53.6.289
State	Published - 2000
Externally published	Yes

Keywords

Comparative genomic hybridisation
Diagnostic pathology
Gene expression
Gene sequencing
Microarray technology

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1136/mp.53.6.289

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title = "Microarray techniques in pathology: Tool or toy?",

abstract = "Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.",

keywords = "Comparative genomic hybridisation, Diagnostic pathology, Gene expression, Gene sequencing, Microarray technology",

author = "Snijders, {A. M.} and Meijer, {G. A.} and Brakenhoff, {R. H.} and {Van den Brule}, {A. J.C.} and {Van Diest}, {P. J.}",

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T2 - Tool or toy?

AU - Snijders, A. M.

AU - Meijer, G. A.

AU - Brakenhoff, R. H.

AU - Van den Brule, A. J.C.

AU - Van Diest, P. J.

PY - 2000

Y1 - 2000

N2 - Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

AB - Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

KW - Comparative genomic hybridisation

KW - Diagnostic pathology

KW - Gene expression

KW - Gene sequencing

KW - Microarray technology

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JO - Journal of Clinical Pathology - Molecular Pathology

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Microarray techniques in pathology: Tool or toy?

Abstract

Keywords

ASJC Scopus subject areas

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