Microarray techniques in pathology: Tool or toy?

A. M. Snijders, G. A. Meijer, R. H. Brakenhoff, A. J C Van den Brule, P. J. Van Diest

Research output: Contribution to journalArticle

Abstract

Microarray technology allows the simultaneous analysis of up to thousands of different genes in histological or cytological specimens. Although microarray technology has so far mainly been applied in the research setting, its clinical application in pathology is expected in the foreseeable future. This paper presents an overview of the technical 'ins and outs' of microarray technology, and discusses several putative applications in diagnostic pathology, which include tumour classification, the prediction of responses to certain chemotherapeutical or hormonal agents, the biological staging of tumours, the risk assessment of premalignant lesions, and the detection of microorganisms.

Original languageEnglish (US)
Pages (from-to)289-294
Number of pages6
JournalJournal of Clinical Pathology
Volume53
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

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Keywords

  • Comparative genomic hybridisation
  • Diagnostic pathology
  • Gene expression
  • Gene sequencing
  • Microarray technology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Snijders, A. M., Meijer, G. A., Brakenhoff, R. H., Van den Brule, A. J. C., & Van Diest, P. J. (2000). Microarray techniques in pathology: Tool or toy? Journal of Clinical Pathology, 53(6), 289-294. https://doi.org/10.1136/mp.53.6.289

Microarray techniques in pathology : Tool or toy? / Snijders, A. M.; Meijer, G. A.; Brakenhoff, R. H.; Van den Brule, A. J C; Van Diest, P. J.

In: Journal of Clinical Pathology, Vol. 53, No. 6, 2000, p. 289-294.

Research output: Contribution to journalArticle

Snijders, AM, Meijer, GA, Brakenhoff, RH, Van den Brule, AJC & Van Diest, PJ 2000, 'Microarray techniques in pathology: Tool or toy?', Journal of Clinical Pathology, vol. 53, no. 6, pp. 289-294. https://doi.org/10.1136/mp.53.6.289
Snijders AM, Meijer GA, Brakenhoff RH, Van den Brule AJC, Van Diest PJ. Microarray techniques in pathology: Tool or toy? Journal of Clinical Pathology. 2000;53(6):289-294. https://doi.org/10.1136/mp.53.6.289
Snijders, A. M. ; Meijer, G. A. ; Brakenhoff, R. H. ; Van den Brule, A. J C ; Van Diest, P. J. / Microarray techniques in pathology : Tool or toy?. In: Journal of Clinical Pathology. 2000 ; Vol. 53, No. 6. pp. 289-294.
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