Microaerosol and nanoparticle synthesis for drug delivery via surface acoustic wave atomization

Mar Alvarez, James Friend, Leslie Yeo, Dian Arifin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the fabrication of a surface acoustic wave (SAW) atomizer, and show its ability to generate monodisperse aerosol and particles for drug delivery applications. In particular, we demonstrate the generation of insulin microdroplets for pulmonary delivery, and polymeric nanoparticles for one-step rapid encapsulation using SAW devices with resonance frequencies of 8.6 MHz and 19.3 MHz. Insulin droplets around 4 ìm were obtained, matching the optimum range for maximising droplet absorption in the alveolar region. Nanoscale polymer particles (130-220 nm in diameter) were obtained through a non-equilbrium evaporation and nucleation process, thereby presenting a quick and simple means for nanoparticle synthesis. These results exhibit the feasibility of SAW as a novel method for producing particles and droplets of controlled sizes.

Original languageEnglish (US)
Title of host publicationProceedings of the 16th Australasian Fluid Mechanics Conference, 16AFMC
Pages621-624
Number of pages4
StatePublished - Dec 1 2007
Event16th Australasian Fluid Mechanics Conference, 16AFMC - Gold Coast, QLD, Australia
Duration: Dec 3 2007Dec 7 2007

Publication series

NameProceedings of the 16th Australasian Fluid Mechanics Conference, 16AFMC

Other

Other16th Australasian Fluid Mechanics Conference, 16AFMC
CountryAustralia
CityGold Coast, QLD
Period12/3/0712/7/07

ASJC Scopus subject areas

  • Fluid Flow and Transfer Processes

Fingerprint Dive into the research topics of 'Microaerosol and nanoparticle synthesis for drug delivery via surface acoustic wave atomization'. Together they form a unique fingerprint.

  • Cite this

    Alvarez, M., Friend, J., Yeo, L., & Arifin, D. (2007). Microaerosol and nanoparticle synthesis for drug delivery via surface acoustic wave atomization. In Proceedings of the 16th Australasian Fluid Mechanics Conference, 16AFMC (pp. 621-624). (Proceedings of the 16th Australasian Fluid Mechanics Conference, 16AFMC).