Micro radiography imaging of the rodent with phenylephrine induced vascular hypertension

Ming De Lin, Laurence Hedlund, G. Allan Johnson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Vascular tonicity plays a major role in regulating the blood pressure and the perfusion of organs, and hypertension is a major cause of morbidity and mortality in humans. We use phenylephrine, a vasoconstrictor, to create a model of hypertension in the rat. This work demonstrates the use of a micro-X-ray digital subtraction angiography (DSA) system to image pharmacologically mediated changes in the vascular system of the rat. Imaging physiological function in the rodent calls for high spatial and temporal resolutions and the use of a reproducible image acquisition chain. Dynamic vascular images and quantitative perfusion metrics were acquired before and after a vasoconstrictor, phenylephrine drug injection. Dramatic effects of the vasoconstrictor on vascular dynamics are seen in the prolonged blood flow mean transit time, amount of ventricular filling, the size increase of the pulmonary arteries and aorta, and a substantial increase in mean arterial pressure.

Original languageEnglish (US)
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages610-613
Number of pages4
StatePublished - Nov 17 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: Apr 6 2006Apr 9 2006

Publication series

Name2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Volume2006

Other

Other2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period4/6/064/9/06

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    De Lin, M., Hedlund, L., & Johnson, G. A. (2006). Micro radiography imaging of the rodent with phenylephrine induced vascular hypertension. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 610-613). [1624990] (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings; Vol. 2006).