Micro-managing and restraining pluripotent stem cells by MYC

Chi V. Dang

Research output: Contribution to journalArticle

Abstract

The MYC proto-oncogene, which encodes a master transcriptional regulator c-Myc (herein termed Myc), has a key role in stem cell (SC) pluripotency and tumourigenesis. Its deregulated expression contributes to cancer development and enhances the efficiency of reprogramming differentiated cells back to a pluripotent state in induced pluripotent SCs (iPSCs) that resemble embryonic SCs (ESCs). In addition to Myc?s ability to directly regulate mRNA transcription, it also directly regulates microRNAs (miRNAs), thus providing an additional level of complexity to gene regulation. However, it had not been well understood how the complex network of Myc target genes contributes to pluripotency in ESCs and to tumourigenesis, two phenomena that are likely inter-related. In this issue of The EMBO Journal, Lin et al (2009) document a role of Myc in the maintenance of murine ESC (mESC) pluripotency through the regulation of a set of miRNAs that suppress differentiation, in addition to those that have been previously implicated in self-renewal capacity.

Original languageEnglish (US)
Pages (from-to)3065-3066
Number of pages2
JournalThe EMBO journal
Volume28
Issue number20
DOIs
StatePublished - Oct 2009

Fingerprint

Pluripotent Stem Cells
Stem cells
MicroRNAs
myc Genes
Proto-Oncogenes
Complex networks
Transcription
Gene expression
Stem Cells
Genes
Maintenance
Messenger RNA
Neoplasms
Cellular Reprogramming

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Medicine(all)

Cite this

Micro-managing and restraining pluripotent stem cells by MYC. / Dang, Chi V.

In: The EMBO journal, Vol. 28, No. 20, 10.2009, p. 3065-3066.

Research output: Contribution to journalArticle

Dang, Chi V. / Micro-managing and restraining pluripotent stem cells by MYC. In: The EMBO journal. 2009 ; Vol. 28, No. 20. pp. 3065-3066.
@article{dd14876b3bb94e1ea09ece589c17c42c,
title = "Micro-managing and restraining pluripotent stem cells by MYC",
abstract = "The MYC proto-oncogene, which encodes a master transcriptional regulator c-Myc (herein termed Myc), has a key role in stem cell (SC) pluripotency and tumourigenesis. Its deregulated expression contributes to cancer development and enhances the efficiency of reprogramming differentiated cells back to a pluripotent state in induced pluripotent SCs (iPSCs) that resemble embryonic SCs (ESCs). In addition to Myc?s ability to directly regulate mRNA transcription, it also directly regulates microRNAs (miRNAs), thus providing an additional level of complexity to gene regulation. However, it had not been well understood how the complex network of Myc target genes contributes to pluripotency in ESCs and to tumourigenesis, two phenomena that are likely inter-related. In this issue of The EMBO Journal, Lin et al (2009) document a role of Myc in the maintenance of murine ESC (mESC) pluripotency through the regulation of a set of miRNAs that suppress differentiation, in addition to those that have been previously implicated in self-renewal capacity.",
author = "Dang, {Chi V.}",
year = "2009",
month = "10",
doi = "10.1038/emboj.2009.293",
language = "English (US)",
volume = "28",
pages = "3065--3066",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Nature Publishing Group",
number = "20",

}

TY - JOUR

T1 - Micro-managing and restraining pluripotent stem cells by MYC

AU - Dang, Chi V.

PY - 2009/10

Y1 - 2009/10

N2 - The MYC proto-oncogene, which encodes a master transcriptional regulator c-Myc (herein termed Myc), has a key role in stem cell (SC) pluripotency and tumourigenesis. Its deregulated expression contributes to cancer development and enhances the efficiency of reprogramming differentiated cells back to a pluripotent state in induced pluripotent SCs (iPSCs) that resemble embryonic SCs (ESCs). In addition to Myc?s ability to directly regulate mRNA transcription, it also directly regulates microRNAs (miRNAs), thus providing an additional level of complexity to gene regulation. However, it had not been well understood how the complex network of Myc target genes contributes to pluripotency in ESCs and to tumourigenesis, two phenomena that are likely inter-related. In this issue of The EMBO Journal, Lin et al (2009) document a role of Myc in the maintenance of murine ESC (mESC) pluripotency through the regulation of a set of miRNAs that suppress differentiation, in addition to those that have been previously implicated in self-renewal capacity.

AB - The MYC proto-oncogene, which encodes a master transcriptional regulator c-Myc (herein termed Myc), has a key role in stem cell (SC) pluripotency and tumourigenesis. Its deregulated expression contributes to cancer development and enhances the efficiency of reprogramming differentiated cells back to a pluripotent state in induced pluripotent SCs (iPSCs) that resemble embryonic SCs (ESCs). In addition to Myc?s ability to directly regulate mRNA transcription, it also directly regulates microRNAs (miRNAs), thus providing an additional level of complexity to gene regulation. However, it had not been well understood how the complex network of Myc target genes contributes to pluripotency in ESCs and to tumourigenesis, two phenomena that are likely inter-related. In this issue of The EMBO Journal, Lin et al (2009) document a role of Myc in the maintenance of murine ESC (mESC) pluripotency through the regulation of a set of miRNAs that suppress differentiation, in addition to those that have been previously implicated in self-renewal capacity.

UR - http://www.scopus.com/inward/record.url?scp=70350325426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350325426&partnerID=8YFLogxK

U2 - 10.1038/emboj.2009.293

DO - 10.1038/emboj.2009.293

M3 - Article

C2 - 19844252

AN - SCOPUS:70350325426

VL - 28

SP - 3065

EP - 3066

JO - EMBO Journal

JF - EMBO Journal

SN - 0261-4189

IS - 20

ER -