Micro-hotspots of risk in urban cholera epidemics

Andrew S. Azman, Francisco J. Luquero, Henrik Salje, Nathan Naibei Mbaïbardoum, Ngandwe Adalbert, Mohammad Ali, Enrico Bertuzzo, Flavio Finger, Brahima Toure, Louis Albert Massing, Romain Ramazani, Bansaga Saga, Maya Allan, David Olson, Jerome Leglise, Klaudia Porten, Justin Lessler

Research output: Contribution to journalArticlepeer-review


Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from urban epidemics in Chad and Democratic Republic of the Congo, we estimate the extent of spatiotemporal zones of increased cholera risk around cases. In both cities, we found zones of increased risk of at least 200 meters during the 5 days immediately after case presentation to a clinic. Risk was highest for those living closest to cases and diminished in time and space similarly across settings. These results provide a rational basis for rapidly delivering targeting interventions.

Original languageEnglish (US)
Pages (from-to)1164-1168
Number of pages5
JournalJournal of Infectious Diseases
Issue number7
StatePublished - Aug 24 2018


  • Cholera
  • Clustering
  • Ring vaccination
  • Targeted interventions
  • Vibrio cholerae

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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