Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa.

Irene Omedo, Polycarp Mogeni, Teun Bousema, Kirk Rockett, Alfred Amambua-Ngwa, Isabella Oyier, Jennifer Claire Stevenson, Amrish Y. Baidjoe, Etienne P. de Villiers, Greg Fegan, Amanda Ross, Christina Hubbart, Anne Jeffreys, Thomas N. Williams, Dominic Kwiatkowski, Philip Bejon

Research output: Contribution to journalArticle

Abstract

Background: The first models of malaria transmission assumed a completely mixed and homogeneous population of parasites. Recent models include spatial heterogeneity and variably mixed populations. However, there are few empiric estimates of parasite mixing with which to parametize such models. Methods: Here we genotype 276 single nucleotide polymorphisms (SNPs) in 5199 P. falciparum isolates from two Kenyan sites and one Gambian site to determine the spatio-temporal extent of parasite mixing, and use Principal Component Analysis (PCA) and linear regression to examine the relationship between genetic relatedness and relatedness in space and time for parasite pairs. Results: We show that there are no discrete geographically restricted parasite sub-populations, but instead we see a diffuse spatio-temporal structure to parasite genotypes. Genetic relatedness of sample pairs is predicted by relatedness in space and time.

Conclusions: Our findings suggest that targeted malaria control will benefit the surrounding community, but unfortunately also that emerging drug resistance will spread rapidly through the population.

Original languageEnglish (US)
Article numberA2
JournalWellcome Open Research
Volume2
DOIs
StatePublished - Jan 1 2017

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Plasmodium falciparum
Parasites
Population
Malaria
Malaria control
Genotype
Principal Component Analysis
Polymorphism
Drug Resistance
Linear regression
Principal component analysis
Single Nucleotide Polymorphism
Linear Models
Nucleotides
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine (miscellaneous)

Cite this

Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa. / Omedo, Irene; Mogeni, Polycarp; Bousema, Teun; Rockett, Kirk; Amambua-Ngwa, Alfred; Oyier, Isabella; Stevenson, Jennifer Claire; Baidjoe, Amrish Y.; de Villiers, Etienne P.; Fegan, Greg; Ross, Amanda; Hubbart, Christina; Jeffreys, Anne; Williams, Thomas N.; Kwiatkowski, Dominic; Bejon, Philip.

In: Wellcome Open Research, Vol. 2, A2, 01.01.2017.

Research output: Contribution to journalArticle

Omedo, I, Mogeni, P, Bousema, T, Rockett, K, Amambua-Ngwa, A, Oyier, I, Stevenson, JC, Baidjoe, AY, de Villiers, EP, Fegan, G, Ross, A, Hubbart, C, Jeffreys, A, Williams, TN, Kwiatkowski, D & Bejon, P 2017, 'Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa.', Wellcome Open Research, vol. 2, A2. https://doi.org/10.12688/wellcomeopenres.10784.1
Omedo, Irene ; Mogeni, Polycarp ; Bousema, Teun ; Rockett, Kirk ; Amambua-Ngwa, Alfred ; Oyier, Isabella ; Stevenson, Jennifer Claire ; Baidjoe, Amrish Y. ; de Villiers, Etienne P. ; Fegan, Greg ; Ross, Amanda ; Hubbart, Christina ; Jeffreys, Anne ; Williams, Thomas N. ; Kwiatkowski, Dominic ; Bejon, Philip. / Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa. In: Wellcome Open Research. 2017 ; Vol. 2.
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