TY - JOUR
T1 - Micro- and nanoengineering for stem cell biology
T2 - The promise with a caution
AU - Kshitiz,
AU - Kim, Deok Ho
AU - Beebe, David J.
AU - Levchenko, Andre
PY - 2011/8
Y1 - 2011/8
N2 - Current techniques used in stem cell research only crudely mimic the physiological complexity of the stem cell niches. Recent advances in the field of micro- and nanoengineering have brought an array of in vitro cell culture models that have enabled development of novel, highly precise and standardized tools that capture physiological details in a single platform, with greater control, consistency, and throughput. In this review, we describe the micro- and nanotechnology-driven modern toolkit for stem cell biologists to design novel experiments in more physiological microenvironments with increased precision and standardization, and caution them against potential challenges that the modern technologies might present.
AB - Current techniques used in stem cell research only crudely mimic the physiological complexity of the stem cell niches. Recent advances in the field of micro- and nanoengineering have brought an array of in vitro cell culture models that have enabled development of novel, highly precise and standardized tools that capture physiological details in a single platform, with greater control, consistency, and throughput. In this review, we describe the micro- and nanotechnology-driven modern toolkit for stem cell biologists to design novel experiments in more physiological microenvironments with increased precision and standardization, and caution them against potential challenges that the modern technologies might present.
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U2 - 10.1016/j.tibtech.2011.03.006
DO - 10.1016/j.tibtech.2011.03.006
M3 - Review article
C2 - 21549437
AN - SCOPUS:79960369437
SN - 0167-7799
VL - 29
SP - 399
EP - 408
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 8
ER -