Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient

Paul S. Lietman, Kan Chiba, Takashi Ishizaki, Hisao Miura, Kimio Minagawa

Research output: Contribution to journalArticle

Abstract

Michaelis-Menten pharmacokinetics were evaluated for diphenylhydantoin given to 104 patients 0.5 to 16 years of age with seizures. A method for individualizing the dosage regimen of DPH for each patient was evaluated retrospectively. The Vmax was inversely related to age (r=-0.552, Pm. The individual pharmacokinetics were characteristic of that person and could be used to adjust dosage so that toxicity would be avoided. We present a nomogram for adjusting the dosage of DPH in the pediatric age groups.

Original languageEnglish (US)
Pages (from-to)479-484
Number of pages6
JournalJournal of Pediatrics
Volume96
Issue number3 PART 1
DOIs
StatePublished - 1980
Externally publishedYes

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Phenytoin
Pharmacokinetics
Pediatrics
Nomograms
Seizures
Age Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient. / Lietman, Paul S.; Chiba, Kan; Ishizaki, Takashi; Miura, Hisao; Minagawa, Kimio.

In: Journal of Pediatrics, Vol. 96, No. 3 PART 1, 1980, p. 479-484.

Research output: Contribution to journalArticle

Lietman, Paul S. ; Chiba, Kan ; Ishizaki, Takashi ; Miura, Hisao ; Minagawa, Kimio. / Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient. In: Journal of Pediatrics. 1980 ; Vol. 96, No. 3 PART 1. pp. 479-484.
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