Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient

Paul S. Lietman; Kan Chiba; Takashi Ishizaki; Hisao Miura; Kimio Minagawa

doi:10.1016/S0022-3476(80)80705-0

Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient

Paul S. Lietman, Kan Chiba, Takashi Ishizaki, Hisao Miura, Kimio Minagawa

School of Medicine

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Michaelis-Menten pharmacokinetics were evaluated for diphenylhydantoin given to 104 patients 0.5 to 16 years of age with seizures. A method for individualizing the dosage regimen of DPH for each patient was evaluated retrospectively. The V_max was inversely related to age (r=-0.552, P<0.001) but there was no such relationship for K_m. The individual pharmacokinetics were characteristic of that person and could be used to adjust dosage so that toxicity would be avoided. We present a nomogram for adjusting the dosage of DPH in the pediatric age groups.

Original language	English (US)
Pages (from-to)	479-484
Number of pages	6
Journal	The Journal of pediatrics
Volume	96
Issue number	3 PART 1
DOIs	https://doi.org/10.1016/S0022-3476(80)80705-0
State	Published - Mar 1980

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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AU - Minagawa, Kimio

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AB - Michaelis-Menten pharmacokinetics were evaluated for diphenylhydantoin given to 104 patients 0.5 to 16 years of age with seizures. A method for individualizing the dosage regimen of DPH for each patient was evaluated retrospectively. The Vmax was inversely related to age (r=-0.552, P<0.001) but there was no such relationship for Km. The individual pharmacokinetics were characteristic of that person and could be used to adjust dosage so that toxicity would be avoided. We present a nomogram for adjusting the dosage of DPH in the pediatric age groups.

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Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient

Abstract

ASJC Scopus subject areas

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