Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient

Paul S. Lietman, Kan Chiba, Takashi Ishizaki, Hisao Miura, Kimio Minagawa

Research output: Contribution to journalArticle

Abstract

Michaelis-Menten pharmacokinetics were evaluated for diphenylhydantoin given to 104 patients 0.5 to 16 years of age with seizures. A method for individualizing the dosage regimen of DPH for each patient was evaluated retrospectively. The Vmax was inversely related to age (r=-0.552, P<0.001) but there was no such relationship for Km. The individual pharmacokinetics were characteristic of that person and could be used to adjust dosage so that toxicity would be avoided. We present a nomogram for adjusting the dosage of DPH in the pediatric age groups.

Original languageEnglish (US)
Pages (from-to)479-484
Number of pages6
JournalThe Journal of pediatrics
Volume96
Issue number3 PART 1
DOIs
StatePublished - Mar 1980

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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