Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

Ronald Lee Schnaar, A. Yamamoto, K. Furukawa, S. Yamashiro, M. Shin, M. Okada, S. Fukumoto, M. Haraguchi, N. Takeda, K. Fujimura, M. Sakae, M. Kishikawa, H. Shiku, K. Furukawa, S. Aizawa

Research output: Contribution to journalArticle

Abstract

Mice genetically engineered to lack complex brain gangliosides developed normal brain anatomy, histology, and ultrastructure, although they demonstrated a modest change in central nervous system conduction velocity.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalChemtracts
Volume11
Issue number3
StatePublished - Mar 1998

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(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase
Gangliosides
Neurology
Nervous System
Brain
Genes
Defects
Histology
Anatomy
Central Nervous System

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Schnaar, R. L., Yamamoto, A., Furukawa, K., Yamashiro, S., Shin, M., Okada, M., ... Aizawa, S. (1998). Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Chemtracts, 11(3), 195-200.

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. / Schnaar, Ronald Lee; Yamamoto, A.; Furukawa, K.; Yamashiro, S.; Shin, M.; Okada, M.; Fukumoto, S.; Haraguchi, M.; Takeda, N.; Fujimura, K.; Sakae, M.; Kishikawa, M.; Shiku, H.; Furukawa, K.; Aizawa, S.

In: Chemtracts, Vol. 11, No. 3, 03.1998, p. 195-200.

Research output: Contribution to journalArticle

Schnaar, RL, Yamamoto, A, Furukawa, K, Yamashiro, S, Shin, M, Okada, M, Fukumoto, S, Haraguchi, M, Takeda, N, Fujimura, K, Sakae, M, Kishikawa, M, Shiku, H, Furukawa, K & Aizawa, S 1998, 'Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system', Chemtracts, vol. 11, no. 3, pp. 195-200.
Schnaar, Ronald Lee ; Yamamoto, A. ; Furukawa, K. ; Yamashiro, S. ; Shin, M. ; Okada, M. ; Fukumoto, S. ; Haraguchi, M. ; Takeda, N. ; Fujimura, K. ; Sakae, M. ; Kishikawa, M. ; Shiku, H. ; Furukawa, K. ; Aizawa, S. / Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. In: Chemtracts. 1998 ; Vol. 11, No. 3. pp. 195-200.
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