Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

R. L. Schnaar, A. Yamamoto, K. Furukawa, S. Yamashiro, M. Shin, M. Okada, S. Fukumoto, M. Haraguchi, N. Takeda, K. Fujimura, M. Sakae, M. Kishikawa, H. Shiku, K. Furukawa, S. Aizawa

Research output: Contribution to journalReview articlepeer-review

Abstract

Mice genetically engineered to lack complex brain gangliosides developed normal brain anatomy, histology, and ultrastructure, although they demonstrated a modest change in central nervous system conduction velocity.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalChemtracts
Volume11
Issue number3
StatePublished - Mar 1998

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Molecular Biology

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