Abstract
A large body of literature has implicated serotonin [5-hydroxytryptamine (5-HT)] in descending modulation of nociceptive transmission. Here, we have studied the pain behavior of Lmx1b conditional knock-out mice (Lmx1b f/f/p), which lack 5-HT neurons in the CNS. Lmx1bf/f/p mutant mice showed normal thermal and visceral pain responses but were less sensitive to mechanical stimuli and exhibited enhanced inflammatory pain compared with their littermate control mice. Importantly, the analgesic effect of several antidepressant drugs, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants, was either abolished or greatly attenuated in Lmx1bf/f/p mice. Moreover, in the acute versus persistent pain settings, the analgesic actions of the SNRI duloxetine and the SSRI fluoxetine were differentially affected. Together, our results provide in vivo genetic evidence demonstrating that although the predominant role of the central 5-HT system in inflammatory pain is inhibitory, its role in acute mechanical pain is facilitatory. The findings that the analgesic effects of various antidepressant drugs are differentially dependent on the central 5-HT system should help us to understand the mechanism of the analgesic action of different classes of antidepressants in the management of persistent pain.
Original language | English (US) |
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Pages (from-to) | 6045-6053 |
Number of pages | 9 |
Journal | Journal of Neuroscience |
Volume | 27 |
Issue number | 22 |
DOIs | |
State | Published - May 30 2007 |
Externally published | Yes |
Keywords
- Analgesic effect
- Antidepressant drugs
- Inflammatory pain
- Lmx1b
- Neurotransmitter
- Serotonin
ASJC Scopus subject areas
- General Neuroscience