MICA and recovery from hepatitis C virus and hepatitis B virus infections

P. S. Karacki, X. Gao, C. L. Thio, D. L. Thomas, J. J. Goedert, D. Vlahov, R. A. Kaslow, S. Strathdee, M. W. Hilgartner, S. J. O'Brien, M. Carrington

Research output: Contribution to journalArticlepeer-review

Abstract

The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8+ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA*015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval=0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA*015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA*015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalGenes and immunity
Volume5
Issue number4
DOIs
StatePublished - Jun 2004

Keywords

  • Genetics
  • HBV
  • HCV
  • MICA
  • Pathogenesis
  • Viral persistence

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

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