TY - JOUR
T1 - MFH and high-grade undifferentiated pleomorphic sarcoma - What's in a name?
AU - Delisca, Gadini O.
AU - Mesko, Nathan W.
AU - Alamanda, Vignesh K.
AU - Archer, Kristin R.
AU - Song, Yanna
AU - Halpern, Jennifer L.
AU - Schwartz, Herbert S.
AU - Holt, Ginger E.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Background and Objectives: In 2002, with the advent of better classification techniques, the World Health Organization declassified malignant fibrous histiocytoma (MFH) as a distinct histological entity in favor of the reclassified entity high-grade undifferentiated pleomorphic sarcoma (HGUPS). To date, no study has evaluated comparative outcomes between patients designated historically in the MFH group and those classified in the new HGUPS classification. Our goal was to determine the presence of clinical prognostic implications that have evolved with this new nomenclature. Methods: Sixty-eight patients were retrospectively evaluated between January 1998 and December 2007. Forty-five patients diagnosed with MFH between 1998 and 2003 were compared to 23 patients in the HGUPS group, from 2004 to 2007. Primary prognostic outcomes assessed included overall survival, metastatic-free, and local recurrence-free survival. Results: Five-year survivorship between MFH and HGUPS populations, using Kaplan-Meier or competing risk methods, did not show statistical difference for overall survival (60% vs. 74%, P = 0.36), 5-year metastasis-free survival (31% vs. 26%, P = 0.67), or local recurrence-free survival (13% vs. 16%, P = 0.62). Conclusion: Despite new classification nomenclature, there appears to be no identifiable prognostic implications for sarcomas that remain in the unclassifiable HGUPS group, as compared to the previously accepted MFH group.
AB - Background and Objectives: In 2002, with the advent of better classification techniques, the World Health Organization declassified malignant fibrous histiocytoma (MFH) as a distinct histological entity in favor of the reclassified entity high-grade undifferentiated pleomorphic sarcoma (HGUPS). To date, no study has evaluated comparative outcomes between patients designated historically in the MFH group and those classified in the new HGUPS classification. Our goal was to determine the presence of clinical prognostic implications that have evolved with this new nomenclature. Methods: Sixty-eight patients were retrospectively evaluated between January 1998 and December 2007. Forty-five patients diagnosed with MFH between 1998 and 2003 were compared to 23 patients in the HGUPS group, from 2004 to 2007. Primary prognostic outcomes assessed included overall survival, metastatic-free, and local recurrence-free survival. Results: Five-year survivorship between MFH and HGUPS populations, using Kaplan-Meier or competing risk methods, did not show statistical difference for overall survival (60% vs. 74%, P = 0.36), 5-year metastasis-free survival (31% vs. 26%, P = 0.67), or local recurrence-free survival (13% vs. 16%, P = 0.62). Conclusion: Despite new classification nomenclature, there appears to be no identifiable prognostic implications for sarcomas that remain in the unclassifiable HGUPS group, as compared to the previously accepted MFH group.
KW - Metastasis
KW - Radiation
KW - Soft tissue sarcoma
KW - Survival
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U2 - 10.1002/jso.23787
DO - 10.1002/jso.23787
M3 - Article
C2 - 25219789
AN - SCOPUS:84921511287
SN - 0022-4790
VL - 111
SP - 173
EP - 177
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 2
ER -