TY - JOUR
T1 - Mexican-American Dementia Nomogram
T2 - Development of a Dementia Risk Index for Mexican-American Older Adults
AU - Downer, Brian
AU - Kumar, Amit
AU - Veeranki, Sreenivas P.
AU - Mehta, Hemalkumar B.
AU - Raji, Mukaila
AU - Markides, Kyriakos S.
N1 - Funding Information:
This work was supported by the National Institute on Aging Contracts 5T32AG00027017 (to BD) and 5R01AG01093922 (to MR and KSM). Conflict of Interest: None. Author Contributions: Downer, Kumar, Veeranki, Mehta, Raji: study conception and design. Downer: data analysis. Markides: data acquisition; Downer and Kumar: writing manuscript. All authors: interpretation of results, substantive edits, manuscript preparation. All authors have given final approval of this version of the manuscript. Sponsor's Role: The sponsors did not play any role in the design, methods, subject recruitment, data collection, analysis, or preparation of this manuscript.
Publisher Copyright:
© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Objectives: To create a risk index (Mexican American Dementia Nomogram (MADeN)) that predicts dementia over a 10-year period for Mexican Americans aged 65 and older. Design: Retrospective cohort study with longitudinal analysis. Setting: Texas, New Mexico, Colorado, Arizona, and California. Participants: Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE) participants (n = 1,739). Measurements: Dementia was defined as a decline of three or more points per year on the Mini-Mental State Examination and inability to perform one or more daily activities. Candidate risk factors included demographic characteristics, measures of social engagement, self-reported health conditions, ability to perform daily activities, and physical activity. Results: The MADeN comprised the following risk factors: age, sex, education, not having friends to count on, not attending community events, diabetes mellitus, feeling the blues, pain, impairment in instrumental activities of daily living, and unable to walk a half-mile. The area under the receiver operating characteristic curve was 0.74 (95% confidence interval (CI) = 0.70–0.78) and a score of 16 points or higher had a sensitivity of 0.65 (95% CI = 0.59–0.72) and specificity of 0.70 (95% CI = 0.67–0.73) in predicting dementia. Conclusion: The MADeN was able to predict dementia in a population of older Mexican-American adults with moderate accuracy. It has the potential to identify older Mexican-American adults who may benefit from interventions to reduce dementia risk and to educate this population about risk factors for dementia.
AB - Objectives: To create a risk index (Mexican American Dementia Nomogram (MADeN)) that predicts dementia over a 10-year period for Mexican Americans aged 65 and older. Design: Retrospective cohort study with longitudinal analysis. Setting: Texas, New Mexico, Colorado, Arizona, and California. Participants: Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE) participants (n = 1,739). Measurements: Dementia was defined as a decline of three or more points per year on the Mini-Mental State Examination and inability to perform one or more daily activities. Candidate risk factors included demographic characteristics, measures of social engagement, self-reported health conditions, ability to perform daily activities, and physical activity. Results: The MADeN comprised the following risk factors: age, sex, education, not having friends to count on, not attending community events, diabetes mellitus, feeling the blues, pain, impairment in instrumental activities of daily living, and unable to walk a half-mile. The area under the receiver operating characteristic curve was 0.74 (95% confidence interval (CI) = 0.70–0.78) and a score of 16 points or higher had a sensitivity of 0.65 (95% CI = 0.59–0.72) and specificity of 0.70 (95% CI = 0.67–0.73) in predicting dementia. Conclusion: The MADeN was able to predict dementia in a population of older Mexican-American adults with moderate accuracy. It has the potential to identify older Mexican-American adults who may benefit from interventions to reduce dementia risk and to educate this population about risk factors for dementia.
KW - Mexican Americans
KW - cognition
KW - dementia
KW - minority aging
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U2 - 10.1111/jgs.14531
DO - 10.1111/jgs.14531
M3 - Article
C2 - 27996114
AN - SCOPUS:84999723675
SN - 0002-8614
VL - 64
SP - e265-e269
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 12
ER -