Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines

Shailesh P. Banerjee, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

A variety of mammalian and avion tissues N- and Q-methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S-adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.

Original languageEnglish (US)
Pages (from-to)74-75
Number of pages2
JournalScience
Volume182
Issue number4107
DOIs
StatePublished - Jan 1 1973

ASJC Scopus subject areas

  • General

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