Methylprednisolone therapy in laser injury of the retina

Tim T. Lam, Kanji Takahashi, Jun Fu, Mark O M Tso

Research output: Contribution to journalArticle

Abstract

The efficacy of methylprednisolone in argon-laser-induced retinal injury in primates was evaluated by clinical, histopathologic, and morphometric criteria. Methylprednisolone was given with a loading dose of 30 mg/kg followed by 5.4 mg/kg per hour in three different regimens: (1) starting 24 h before laser and continuing for 4 days; (2) starting immediately after laser and continuing for 4 days; and (3) starting immediately after laser and continuing for 8 h. Fundus photography, fluorescein angiography, and histologic examination showed significant beneficial effects of all three treatments compared to controls. Morphometrically, at the center of the lesion, the width of disrupted outer nuclear layer, the width of the affected RPE, and the percentage of residual photoreceptor nuclei confirmed the efficacies of treatment regimens 1 and 2, but not treatment regimen 3.

Original languageEnglish (US)
Pages (from-to)729-736
Number of pages8
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume231
Issue number12
DOIs
Publication statusPublished - Dec 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Ophthalmology

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