Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies

Dimitrios Farmakiotis, Fazal Shirazi, Yanan Zhao, Peguy J. Saad, Nathaniel D. Albert, Emmanuel Roilides, Thomas J. Walsh, David S. Perlin, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticlepeer-review

Abstract

High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.

Original languageEnglish (US)
Pages (from-to)1471-1475
Number of pages5
JournalJournal of Infectious Diseases
Volume210
Issue number9
DOIs
StatePublished - Nov 1 2014

Keywords

  • Animal models
  • Apoptosis
  • Corticosteroids
  • Exserohilum rostratum
  • Virulence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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