Methylprednisolone ameliorates laser induced retinal injury in rats

M. Rosner, M. Tchirkov, G. Dubinski, N. Naveh, M. O.M. Tso

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. Methylprednisolone has been demonstrated to ameliorate retinal photic injury. In the current study we examined its effect on laser induced retinal injury. Methods. Retinal lesions were inflicted by Argon laser (0.05 W, 0.1 sec, 200 micrometer) in 36 pigmented DA rats. The treated groups received intaperitoneally methylprednisolone (160 mg/kg/day) in saline, injected 3 times a day for 2 days, starting immediately after exposure. The controls received saline on the same schedule. The rats were sacrificed 3, 20 or 60 days after laser exposure and the retinal lesions were evaluated by light microscopy and morphometric measurements. Results. Laser injuries were associated with disruption of the outer retinal layers. No difference in the diameter of the lesions between the treated and control groups was noted. However, the area of total ONL loss at the center of the lesion was smaller and the loss of ONL thickness at the area of the lesion was significantly milder in the treated group as compared with controls (17.3 Vs. 24.1 micrometer, treated and control respectively, 20 days following exposure, p=0.00008). Conclusions. Methylprednisolone reduced the photoreceptor cell loss in argon laser induced retinal injury, when treatment was started immediately after laser exposure.

Original languageEnglish (US)
Pages (from-to)S694
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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