Methylmercury and neurodevelopment

Longitudinal analysis of the Seychelles child development cohort

Philip W. Davidson, Gary J. Myers, Christopher Cox, Gregory E. Wilding, Conrad F. Shamlaye, Li Shan Huang, Elsa Cernichiari, Jean Sloane-Reeves, Donna Palumbo, Thomas W. Clarkson

Research output: Contribution to journalArticle

Abstract

Background: The Seychelles Child Development Study (SCDS) has been longitudinally following a cohort of over 700 children enrolled in 1989. Their mothers consumed a diet high in fish during pregnancy. Repeated examination of the SCDS cohort at six different ages through age 11 years has shown no pattern of adverse effects. Some early appearing beneficial associations between both prenatal and postnatal hair MeHg and several child development endpoints were noted. We hypothesized these might be related to micronutrients in the fish, but they were not found when the children reached middle school age. These findings suggest that the associations observed between MeHg and developmental outcomes may vary with developmental stage. Method: We examined the main cohort of the SCDS to determine if this might be true using a longitudinal multiple regression analysis design that focused on those endpoints that were repeatedly measured at different ages. The primary endpoint analyzed was global cognition, involving a measure of developmental quotient or IQ. Secondary analyses included other domains such as Reading and Mathematics scholastic achievement, social behavior, and memory. Analyses involved two different approaches, one including incorporation of a passage of time variable, the other including a difference of scores across time points. Results: No significant associations were found between prenatal MeHg exposure and any of the repeatedly measured endpoints. Conclusions: These results suggest that even when individual subject variance is controlled there was no consistent pattern of associations between child development outcomes and prenatal exposures to MeHg from maternal consumption of a diet high in fish. The Seychellois diet contains about 10 times more ocean fish than is typically consumed by US citizens. Our primary focus on IQ should further inform growing scientific interest in the analysis of the risks and benefits of fish consumption on overall cognitive ability.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalNeurotoxicology and Teratology
Volume28
Issue number5
DOIs
StatePublished - Sep 2006

Fingerprint

Seychelles
Child Development
Fish
Fishes
Nutrition
Diet
Mothers
Aptitude
Mathematics
Social Behavior
Micronutrients
Regression analysis
Oceans and Seas
Hair
Cognition
Reading
Cohort Studies
Regression Analysis
Data storage equipment
Pregnancy

Keywords

  • Child development
  • Longitudinal analysis
  • Methylmercury

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Davidson, P. W., Myers, G. J., Cox, C., Wilding, G. E., Shamlaye, C. F., Huang, L. S., ... Clarkson, T. W. (2006). Methylmercury and neurodevelopment: Longitudinal analysis of the Seychelles child development cohort. Neurotoxicology and Teratology, 28(5), 529-535. https://doi.org/10.1016/j.ntt.2006.06.002

Methylmercury and neurodevelopment : Longitudinal analysis of the Seychelles child development cohort. / Davidson, Philip W.; Myers, Gary J.; Cox, Christopher; Wilding, Gregory E.; Shamlaye, Conrad F.; Huang, Li Shan; Cernichiari, Elsa; Sloane-Reeves, Jean; Palumbo, Donna; Clarkson, Thomas W.

In: Neurotoxicology and Teratology, Vol. 28, No. 5, 09.2006, p. 529-535.

Research output: Contribution to journalArticle

Davidson, PW, Myers, GJ, Cox, C, Wilding, GE, Shamlaye, CF, Huang, LS, Cernichiari, E, Sloane-Reeves, J, Palumbo, D & Clarkson, TW 2006, 'Methylmercury and neurodevelopment: Longitudinal analysis of the Seychelles child development cohort', Neurotoxicology and Teratology, vol. 28, no. 5, pp. 529-535. https://doi.org/10.1016/j.ntt.2006.06.002
Davidson, Philip W. ; Myers, Gary J. ; Cox, Christopher ; Wilding, Gregory E. ; Shamlaye, Conrad F. ; Huang, Li Shan ; Cernichiari, Elsa ; Sloane-Reeves, Jean ; Palumbo, Donna ; Clarkson, Thomas W. / Methylmercury and neurodevelopment : Longitudinal analysis of the Seychelles child development cohort. In: Neurotoxicology and Teratology. 2006 ; Vol. 28, No. 5. pp. 529-535.
@article{c87de4f3135847ffb099d815bcbc636f,
title = "Methylmercury and neurodevelopment: Longitudinal analysis of the Seychelles child development cohort",
abstract = "Background: The Seychelles Child Development Study (SCDS) has been longitudinally following a cohort of over 700 children enrolled in 1989. Their mothers consumed a diet high in fish during pregnancy. Repeated examination of the SCDS cohort at six different ages through age 11 years has shown no pattern of adverse effects. Some early appearing beneficial associations between both prenatal and postnatal hair MeHg and several child development endpoints were noted. We hypothesized these might be related to micronutrients in the fish, but they were not found when the children reached middle school age. These findings suggest that the associations observed between MeHg and developmental outcomes may vary with developmental stage. Method: We examined the main cohort of the SCDS to determine if this might be true using a longitudinal multiple regression analysis design that focused on those endpoints that were repeatedly measured at different ages. The primary endpoint analyzed was global cognition, involving a measure of developmental quotient or IQ. Secondary analyses included other domains such as Reading and Mathematics scholastic achievement, social behavior, and memory. Analyses involved two different approaches, one including incorporation of a passage of time variable, the other including a difference of scores across time points. Results: No significant associations were found between prenatal MeHg exposure and any of the repeatedly measured endpoints. Conclusions: These results suggest that even when individual subject variance is controlled there was no consistent pattern of associations between child development outcomes and prenatal exposures to MeHg from maternal consumption of a diet high in fish. The Seychellois diet contains about 10 times more ocean fish than is typically consumed by US citizens. Our primary focus on IQ should further inform growing scientific interest in the analysis of the risks and benefits of fish consumption on overall cognitive ability.",
keywords = "Child development, Longitudinal analysis, Methylmercury",
author = "Davidson, {Philip W.} and Myers, {Gary J.} and Christopher Cox and Wilding, {Gregory E.} and Shamlaye, {Conrad F.} and Huang, {Li Shan} and Elsa Cernichiari and Jean Sloane-Reeves and Donna Palumbo and Clarkson, {Thomas W.}",
year = "2006",
month = "9",
doi = "10.1016/j.ntt.2006.06.002",
language = "English (US)",
volume = "28",
pages = "529--535",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Methylmercury and neurodevelopment

T2 - Longitudinal analysis of the Seychelles child development cohort

AU - Davidson, Philip W.

AU - Myers, Gary J.

AU - Cox, Christopher

AU - Wilding, Gregory E.

AU - Shamlaye, Conrad F.

AU - Huang, Li Shan

AU - Cernichiari, Elsa

AU - Sloane-Reeves, Jean

AU - Palumbo, Donna

AU - Clarkson, Thomas W.

PY - 2006/9

Y1 - 2006/9

N2 - Background: The Seychelles Child Development Study (SCDS) has been longitudinally following a cohort of over 700 children enrolled in 1989. Their mothers consumed a diet high in fish during pregnancy. Repeated examination of the SCDS cohort at six different ages through age 11 years has shown no pattern of adverse effects. Some early appearing beneficial associations between both prenatal and postnatal hair MeHg and several child development endpoints were noted. We hypothesized these might be related to micronutrients in the fish, but they were not found when the children reached middle school age. These findings suggest that the associations observed between MeHg and developmental outcomes may vary with developmental stage. Method: We examined the main cohort of the SCDS to determine if this might be true using a longitudinal multiple regression analysis design that focused on those endpoints that were repeatedly measured at different ages. The primary endpoint analyzed was global cognition, involving a measure of developmental quotient or IQ. Secondary analyses included other domains such as Reading and Mathematics scholastic achievement, social behavior, and memory. Analyses involved two different approaches, one including incorporation of a passage of time variable, the other including a difference of scores across time points. Results: No significant associations were found between prenatal MeHg exposure and any of the repeatedly measured endpoints. Conclusions: These results suggest that even when individual subject variance is controlled there was no consistent pattern of associations between child development outcomes and prenatal exposures to MeHg from maternal consumption of a diet high in fish. The Seychellois diet contains about 10 times more ocean fish than is typically consumed by US citizens. Our primary focus on IQ should further inform growing scientific interest in the analysis of the risks and benefits of fish consumption on overall cognitive ability.

AB - Background: The Seychelles Child Development Study (SCDS) has been longitudinally following a cohort of over 700 children enrolled in 1989. Their mothers consumed a diet high in fish during pregnancy. Repeated examination of the SCDS cohort at six different ages through age 11 years has shown no pattern of adverse effects. Some early appearing beneficial associations between both prenatal and postnatal hair MeHg and several child development endpoints were noted. We hypothesized these might be related to micronutrients in the fish, but they were not found when the children reached middle school age. These findings suggest that the associations observed between MeHg and developmental outcomes may vary with developmental stage. Method: We examined the main cohort of the SCDS to determine if this might be true using a longitudinal multiple regression analysis design that focused on those endpoints that were repeatedly measured at different ages. The primary endpoint analyzed was global cognition, involving a measure of developmental quotient or IQ. Secondary analyses included other domains such as Reading and Mathematics scholastic achievement, social behavior, and memory. Analyses involved two different approaches, one including incorporation of a passage of time variable, the other including a difference of scores across time points. Results: No significant associations were found between prenatal MeHg exposure and any of the repeatedly measured endpoints. Conclusions: These results suggest that even when individual subject variance is controlled there was no consistent pattern of associations between child development outcomes and prenatal exposures to MeHg from maternal consumption of a diet high in fish. The Seychellois diet contains about 10 times more ocean fish than is typically consumed by US citizens. Our primary focus on IQ should further inform growing scientific interest in the analysis of the risks and benefits of fish consumption on overall cognitive ability.

KW - Child development

KW - Longitudinal analysis

KW - Methylmercury

UR - http://www.scopus.com/inward/record.url?scp=33750697657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750697657&partnerID=8YFLogxK

U2 - 10.1016/j.ntt.2006.06.002

DO - 10.1016/j.ntt.2006.06.002

M3 - Article

VL - 28

SP - 529

EP - 535

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 5

ER -