Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex

Michael V. Johnston; Reinhard Grzanna; Joseph T. Coyle

doi:10.1126/science.32620

Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex

Michael V. Johnston, Reinhard Grzanna, Joseph T. Coyle

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

A single injection of methylazoxymethanol in pregnant rats at 15 days of gestation results in severe cortical atrophy in the offspring. In the adult offspring, the neurochemical markers for the cortical γ-aminobutyric acid-containing neurons are severely reduced, whereas the noradrenergic markers are minimally altered. Immunohistofluorescence microscopy demonstrates a marked increase in the density of noradrenergic axons which have an abnormal pattern of distribution in the atrophic cortex. The results suggest that the central noradrenergic neurons determine the number of axons to be formed early in brain development, but local factors in the terminal field regulate the ultimate distribution of the noradrenergic axons.

Original language	English (US)
Pages (from-to)	369-371
Number of pages	3
Journal	Science
Volume	203
Issue number	4378
DOIs	https://doi.org/10.1126/science.32620
State	Published - 1979

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title = "Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex",

abstract = "A single injection of methylazoxymethanol in pregnant rats at 15 days of gestation results in severe cortical atrophy in the offspring. In the adult offspring, the neurochemical markers for the cortical γ-aminobutyric acid-containing neurons are severely reduced, whereas the noradrenergic markers are minimally altered. Immunohistofluorescence microscopy demonstrates a marked increase in the density of noradrenergic axons which have an abnormal pattern of distribution in the atrophic cortex. The results suggest that the central noradrenergic neurons determine the number of axons to be formed early in brain development, but local factors in the terminal field regulate the ultimate distribution of the noradrenergic axons.",

author = "Johnston, {Michael V.} and Reinhard Grzanna and Coyle, {Joseph T.}",

year = "1979",

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AU - Johnston, Michael V.

AU - Grzanna, Reinhard

AU - Coyle, Joseph T.

PY - 1979

Y1 - 1979

N2 - A single injection of methylazoxymethanol in pregnant rats at 15 days of gestation results in severe cortical atrophy in the offspring. In the adult offspring, the neurochemical markers for the cortical γ-aminobutyric acid-containing neurons are severely reduced, whereas the noradrenergic markers are minimally altered. Immunohistofluorescence microscopy demonstrates a marked increase in the density of noradrenergic axons which have an abnormal pattern of distribution in the atrophic cortex. The results suggest that the central noradrenergic neurons determine the number of axons to be formed early in brain development, but local factors in the terminal field regulate the ultimate distribution of the noradrenergic axons.

AB - A single injection of methylazoxymethanol in pregnant rats at 15 days of gestation results in severe cortical atrophy in the offspring. In the adult offspring, the neurochemical markers for the cortical γ-aminobutyric acid-containing neurons are severely reduced, whereas the noradrenergic markers are minimally altered. Immunohistofluorescence microscopy demonstrates a marked increase in the density of noradrenergic axons which have an abnormal pattern of distribution in the atrophic cortex. The results suggest that the central noradrenergic neurons determine the number of axons to be formed early in brain development, but local factors in the terminal field regulate the ultimate distribution of the noradrenergic axons.

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Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex

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