Methylazoxymethanol treatment of fetal rats results in abnormally dense noradrenergic innervation of neocortex

Michael V. Johnston, Reinhard Grzanna, Joseph T. Coyle

Research output: Contribution to journalArticlepeer-review

Abstract

A single injection of methylazoxymethanol in pregnant rats at 15 days of gestation results in severe cortical atrophy in the offspring. In the adult offspring, the neurochemical markers for the cortical γ-aminobutyric acid-containing neurons are severely reduced, whereas the noradrenergic markers are minimally altered. Immunohistofluorescence microscopy demonstrates a marked increase in the density of noradrenergic axons which have an abnormal pattern of distribution in the atrophic cortex. The results suggest that the central noradrenergic neurons determine the number of axons to be formed early in brain development, but local factors in the terminal field regulate the ultimate distribution of the noradrenergic axons.

Original languageEnglish (US)
Pages (from-to)369-371
Number of pages3
JournalScience
Volume203
Issue number4378
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • General

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