Methylazoxymethanol acetate ablation of mouse cerebellar granule cells: Effects on synaptic neurochemistry

J. T. Slevin, M. V. Johnston, K. Biziere, J. T. Coyle

Research output: Contribution to journalArticle

Abstract

Mice whose cerebella were rendered granuloprival by neonatal injection of methylazoxymethanol had decreased cerebellar adult levels of glutamic acid (GA) (-29%), decreased GA presynaptic uptake (-45%) and increased GA postsynaptic binding (+65%) compared to controls, suggesting that GA is the neurotransmitter of cerebellar granule cells. Total binding for the β-adrenergic receptor, the muscarinic cholinergic receptor and the kainic acid receptor fell commensurate with the degree of cerebellar hypoplasia. In contrast, increases in glutamic acid decarboxylase (+59%), γ-aminobutyric acid (GABA) uptake (+52%), and endogenous GABA levels (+29%) and a decrease in GABA binding (-32%) favor GABA as the neurotransmitter of other cerebellar interneurons.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalDevelopmental Neuroscience
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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