Methoxychlor inhibits growth and induces atresia through the aryl hydrocarbon receptor pathway in mouse ovarian antral follicles

Mallikarjuna S. Basavarajappa, Isabel Hernández-Ochoa, Wei Wang, Jodi A. Flaws

Research output: Contribution to journalArticle

Abstract

Methoxychlor (MXC) is an organochlorine pesticide used against pests that attack crops, vegetables, and livestock. MXC inhibits growth and induces atresia (death) of mouse ovarian antral follicles in vitro. Since several studies indicate that many chemicals act through the aryl hydrocarbon receptor (AHR) pathway, the current study tested the hypothesis that MXC binds to the AHR to inhibit growth and induce atresia of antral follicles. The data indicate that MXC binds to AHR. Further, a relatively high dose of MXC (100μg/ml) inhibits growth and induces atresia in both wild-type (WT) and AHR null (AHRKO) follicles, whereas a lower dose of MXC (10μg/ml) inhibits growth and induces atresia in WT, but not in AHRKO follicles. These data indicate that AHR deletion partially protects antral follicles from MXC induced slow growth and atresia. Collectively, these data show that MXC may act through the AHR pathway to inhibit follicle growth and induce atresia in antral follicles of the ovary.

Original languageEnglish (US)
Pages (from-to)16-21
Number of pages6
JournalReproductive Toxicology
Volume34
Issue number1
DOIs
StatePublished - Aug 2012
Externally publishedYes

Keywords

  • Antral follicles
  • Aryl hydrocarbon receptor
  • Atresia
  • Growth
  • Methoxychlor
  • Mouse
  • Ovary

ASJC Scopus subject areas

  • Toxicology

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