Methotrexate cytotoxicity: Studies on its reversal by folates and nucleosides

A. Leyva, H. Nederbragt, J. Lankelma, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

The methotrexate (MTX) metabolite, 7-hydroxymethotrexate, which is potentially capable of influencing MTX rescue by affecting both MTX and reduced folate transport at the cell membrane, has been estimated in the plasma of patients receiving moderate doses (240 mg/m2) of MTX. Forty-eight hours after MTX dosage the level of 7-hydroxymethotrexate exceeded that of MTX by ten to one. Studies of the utilization of thymidine and inosine by MTX-treated L1210 cells in culture suggest that these cells may be able to utilize these substrates when their extracellular concentration is

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalCancer Treatment Reports
Volume65
Issue numberSuppl.1
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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