Methods for the detection of gasotransmitters

Hanjing Peng, Weixuan Chen, Binghe Wang

Research output: Chapter in Book/Report/Conference proceedingChapter


The discovery of gasotransmitters, such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), represents great milestones in biology. Both the discovery and related study of these gasotransmitters have benefited from selective and sensitive detection methods. This chapter has briefly reviewed and compared the methods used for the detection and determination of these three gasotransmitters. For NO, the detection methods include small molecule organic chemoprobes, transition metal-based probes, capillary electrophoresis (CE), NO-selective electrodes, and protein-based probes. For H2S, the detection methods include chromatographic methods such as gas chromatography (GC) and high performance liquid chromatography (HPLC), reaction-based spectrophotometric methods such as fluorescent chemoprobes and electrochemical methods. CO detection in biological systems mainly focuses on measurement of carboxyhemoglobin (COHb) saturation. Methods such as spectrophotometric methods, GC, and electrochemical methods are used in this field.

Original languageEnglish (US)
Title of host publicationGasotransmitters
Subtitle of host publicationPhysiology and Pathophysiology
PublisherSpringer-Verlag Berlin Heidelberg
Number of pages39
ISBN (Electronic)9783642303388
ISBN (Print)3642303374, 9783642303371
StatePublished - Aug 1 2012
Externally publishedYes


  • Carbon monoxide
  • Chemoprobes
  • Chemosensors
  • Detection methods
  • Gasotransmitters
  • Hydrogen sulfide
  • Nitric oxide

ASJC Scopus subject areas

  • Medicine(all)


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