Several transient receptor potential (TRP) ion channels are activated by heat and may potentially -contribute to human heat perception though clinical data are currently either limited or absent. At least three of the identified heat-activated TRP channels are appealing drug targets for multiple potential therapeutic indications. Evaluation of heat perception in clinical development programs will improve drug characterization, highlight potential safety issues related to heat insensitivity, and clarify the role of these channels in human heat sensation. Multiple facets of heat perception may feasibly be assessed in the clinical research unit (CRU) setting using established methods and commercially available equipment including temperature-controlled contact thermodes and circulating water baths. Established methods are reviewed for the assessment of heat perception thresholds and multiple facets of heat perception. An exploratory approach to initial assessment of household burn risk is discussed as well.