Methods for noninvasive imaging of tissue hypoxia

Deepti S. Vikram, Jay L. Zweier, Periannan Kuppusamy

Research output: Contribution to journalArticle

Abstract

The purpose of this review is to provide an overview of the methods available for imaging tissue oxygenation. The following imaging methods are reviewed: phosphorescence, near-infrared (NIR), positron emission tomography (PET), magnetic resonance imaging (19F MRI and BOLD MRI), and electron paramagnetic resonance (EPR). The methods are based on different principles and differ in their ability to accurately quantify tissue oxygenation, either the absolute value of a particular measure of oxygenation (partial pressure of oxygen, concentration), or a parameter related to it (oxygen saturation). Methods that can provide images of relative changes in oxygenation or visualization of hypoxia in a specific tissue of interest are also considered valuable tools for biomedical research and clinical applications.

Original languageEnglish (US)
Pages (from-to)1745-1756
Number of pages12
JournalAntioxidants and Redox Signaling
Volume9
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

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Partial Pressure
Partial pressure
Tissue
Oxygen
Imaging techniques
Magnetic resonance imaging
Phosphorescence
Positron emission tomography
Electron Spin Resonance Spectroscopy
Magnetic resonance
Positron-Emission Tomography
Paramagnetic resonance
Biomedical Research
Visualization
Magnetic Resonance Imaging
Hypoxia
Infrared radiation

ASJC Scopus subject areas

  • Biochemistry

Cite this

Methods for noninvasive imaging of tissue hypoxia. / Vikram, Deepti S.; Zweier, Jay L.; Kuppusamy, Periannan.

In: Antioxidants and Redox Signaling, Vol. 9, No. 10, 10.2007, p. 1745-1756.

Research output: Contribution to journalArticle

Vikram, DS, Zweier, JL & Kuppusamy, P 2007, 'Methods for noninvasive imaging of tissue hypoxia', Antioxidants and Redox Signaling, vol. 9, no. 10, pp. 1745-1756. https://doi.org/10.1089/ars.2007.1717
Vikram, Deepti S. ; Zweier, Jay L. ; Kuppusamy, Periannan. / Methods for noninvasive imaging of tissue hypoxia. In: Antioxidants and Redox Signaling. 2007 ; Vol. 9, No. 10. pp. 1745-1756.
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