Abstract
In many areas of medical research, 'gold standard' diagnostic tests do not exist and so evaluating the performance of standardized diagnostic criteria or algorithms is problematic. In this paper we propose an approach to evaluating the operating characteristics of diagnoses using a latent class model. By defining 'true disease' as our latent variable, we are able to estimate sensitivity, specificity and negative and positive predictive values of the diagnostic test. These methods are applied to diagnostic criteria for depression using Baltimore's Epidemiologic Catchment Area Study Wave 3 data.
Original language | English (US) |
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Pages (from-to) | 1289-1307 |
Number of pages | 19 |
Journal | Statistics in Medicine |
Volume | 21 |
Issue number | 9 |
DOIs | |
State | Published - May 15 2002 |
Keywords
- Depression
- Diagnostic criteria
- Latent class models
- Markov chain Monte Carlo
- Operating characteristics
- Validation
ASJC Scopus subject areas
- Epidemiology
- Statistics and Probability