TY - JOUR
T1 - Methods for a systematic review of pneumococcal conjugate vaccine dosing schedules
AU - Loo, Jennifer D.
AU - Conklin, Laura
AU - Knoll, Maria Deloria
AU - Fleming-Dutra, Katherine E.
AU - Park, Daniel E.
AU - Kirk, Jennifer
AU - Johnson, T. Scott
AU - Goldblatt, David
AU - O'Brien, Katherine L.
AU - Whitney, Cynthia G.
PY - 2014
Y1 - 2014
N2 - Background: Streptococcus pneumoniae causes a considerable amount of morbidity and mortality in children <5. However, pneumococcal conjugate vaccines (PCVs) can prevent much of this burden. Until recently, PCVs were mostly available only in developed countries using a variety of dosing schedules. As more lower income countries make decisions to introduce PCV into their national immunization programs, an optimal schedule with which to administer PCV has become a key policy question. Methods: We performed a systematic review of English literature published from 1994 to 2010 on the effects of PCV dosing schedules on immunogenicity, nasopharyngeal carriage, invasive pneumococcal disease and pneumonia. Data were independently double abstracted and cleaned for analysis. Descriptive analyses were performed. Results: We identified 12,980 citations from the literature search (12,976) and secondary means (44). Double review of titles and abstracts yielded 769 articles that underwent full data abstraction. Of these, 350 were further analyzed and are presented in separate reports in this supplement. Conclusions: This article presents the methods utilized in our systematic review. Because of the heterogenity of the study methods of the reports identified by this review, we did not conduct formal meta-analyses. However, these methods allow us to present a full landscape of the literature on PCV dosing schedules.
AB - Background: Streptococcus pneumoniae causes a considerable amount of morbidity and mortality in children <5. However, pneumococcal conjugate vaccines (PCVs) can prevent much of this burden. Until recently, PCVs were mostly available only in developed countries using a variety of dosing schedules. As more lower income countries make decisions to introduce PCV into their national immunization programs, an optimal schedule with which to administer PCV has become a key policy question. Methods: We performed a systematic review of English literature published from 1994 to 2010 on the effects of PCV dosing schedules on immunogenicity, nasopharyngeal carriage, invasive pneumococcal disease and pneumonia. Data were independently double abstracted and cleaned for analysis. Descriptive analyses were performed. Results: We identified 12,980 citations from the literature search (12,976) and secondary means (44). Double review of titles and abstracts yielded 769 articles that underwent full data abstraction. Of these, 350 were further analyzed and are presented in separate reports in this supplement. Conclusions: This article presents the methods utilized in our systematic review. Because of the heterogenity of the study methods of the reports identified by this review, we did not conduct formal meta-analyses. However, these methods allow us to present a full landscape of the literature on PCV dosing schedules.
KW - Immunization schedule
KW - Methods
KW - Pneumococcal conjugate vaccine
KW - Systematic review
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U2 - 10.1097/INF.0000000000000085
DO - 10.1097/INF.0000000000000085
M3 - Review article
C2 - 24336060
AN - SCOPUS:84891396415
SN - 0891-3668
VL - 33
SP - S182-S187
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - SUPPL. 2
ER -