Methodology, design, and analytic techniques to address measurement of comorbid disease

Timothy L. Lash, Vincent Mor, Darryl Wieland, Luigi Ferrucci, William Satariano, Rebecca A. Silliman

Research output: Contribution to journalArticle

Abstract

Background. Measurement of comorbidity affects all variable axes that are considered in health care research: confounding, modifying, independent, and dependent variable. Comorbidity measurement particularly affects research involving older adults because they bear the disproportionate share of the comorbidity burden. Methods. We examine how well researchers can expect to segregate study participants into those who are healthier and those who are less healthy, given the variable axis for which they are measuring comorbidity, the comorbidity measure they select, and the analytic method they choose. We also examine the impact of poor measurement of comorbidity. Results. Available comorbidity measures make use of medical records, self-report, physician assessments, and administrative databases. Analyses using these scales introduce uncertainties that can be framed as measurement error or misclassification problems, and can be addressed by extant analytic methods. Newer analytic methods make efficient use of multiple sources of comorbidity information. Conclusions. Consideration of the comorbidity measure, its role in the analysis, and analogous measurement error problems will yield an analytic solution and an appreciation for the likely direction and magnitude of the biases introduced.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume62
Issue number3
StatePublished - Mar 2007
Externally publishedYes

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Comorbidity
Health Services Research
Self Report
Uncertainty
Medical Records
Research Personnel
Databases
Physicians
Research

ASJC Scopus subject areas

  • Aging

Cite this

Lash, T. L., Mor, V., Wieland, D., Ferrucci, L., Satariano, W., & Silliman, R. A. (2007). Methodology, design, and analytic techniques to address measurement of comorbid disease. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 62(3), 281-285.

Methodology, design, and analytic techniques to address measurement of comorbid disease. / Lash, Timothy L.; Mor, Vincent; Wieland, Darryl; Ferrucci, Luigi; Satariano, William; Silliman, Rebecca A.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 62, No. 3, 03.2007, p. 281-285.

Research output: Contribution to journalArticle

Lash, TL, Mor, V, Wieland, D, Ferrucci, L, Satariano, W & Silliman, RA 2007, 'Methodology, design, and analytic techniques to address measurement of comorbid disease', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 62, no. 3, pp. 281-285.
Lash, Timothy L. ; Mor, Vincent ; Wieland, Darryl ; Ferrucci, Luigi ; Satariano, William ; Silliman, Rebecca A. / Methodology, design, and analytic techniques to address measurement of comorbid disease. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2007 ; Vol. 62, No. 3. pp. 281-285.
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