Methodological issues in genetic studies of human substance abuse

Dace S. Svikis, Roy W. Pickens

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


This paper described a number of critical assumptions and methodological issues that influence the interpretation of data from family, twin and adoption studies of substance abuse. Also, using data from a recent study, it examined the tole of one methodological issue (method of zygosity determination) and one critical assumption (representativeness of twins as research subjects) to determine the validity of data in twin studies of substance abuse. The accuracy of the questionnaire methods for zygosity determination in alcoholic twins was similar to that previously reported for nonalcoholic twins. Also, alcoholic twins were found to be representative of both nonalcoholic twins and alcoholics in general.

Original languageEnglish (US)
Pages (from-to)215-228
Number of pages14
JournalJournal of Addictive Diseases
Issue number1-2
StatePublished - Apr 12 1991

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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