Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Yu Wang, Hongying An, Ting Liu, Caolitao Qin, Hiromi Sesaki, Shaodong Guo, Sally Radovick, Mehboob Hussain, Akhil Maheshwari, Fredric E. Wondisford, Brian O'Rourke, Ling He

Research output: Contribution to journalArticle

Abstract

The mechanism of metformin action still remains controversial, in particular on mitochondrial activity and the involvement of AMPK. Wang et al. show that pharmacological metformin concentration or dose improves mitochondrial respiration by increasing mitochondrial fission through AMPK-Mff signaling; in contrast, supra-pharmacological metformin concentrations reduce mitochondrial respiration through decreasing adenine nucleotide levels.

Original languageEnglish (US)
Pages (from-to)1511-1523.e5
JournalCell Reports
Volume29
Issue number6
DOIs
StatePublished - Nov 5 2019

Fingerprint

AMP-Activated Protein Kinases
Metformin
Chemical activation
Respiration
Pharmacology
Mitochondrial Dynamics
Adenine Nucleotides

Keywords

  • adenine nucleotides
  • AMPK
  • diabetes
  • Drp1
  • insulin resistance
  • membrane potential
  • metformin
  • mitochondrial respiration/fission

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. / Wang, Yu; An, Hongying; Liu, Ting; Qin, Caolitao; Sesaki, Hiromi; Guo, Shaodong; Radovick, Sally; Hussain, Mehboob; Maheshwari, Akhil; Wondisford, Fredric E.; O'Rourke, Brian; He, Ling.

In: Cell Reports, Vol. 29, No. 6, 05.11.2019, p. 1511-1523.e5.

Research output: Contribution to journalArticle

Wang, Yu ; An, Hongying ; Liu, Ting ; Qin, Caolitao ; Sesaki, Hiromi ; Guo, Shaodong ; Radovick, Sally ; Hussain, Mehboob ; Maheshwari, Akhil ; Wondisford, Fredric E. ; O'Rourke, Brian ; He, Ling. / Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. In: Cell Reports. 2019 ; Vol. 29, No. 6. pp. 1511-1523.e5.
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