The mechanism of metformin action still remains controversial, in particular on mitochondrial activity and the involvement of AMPK. Wang et al. show that pharmacological metformin concentration or dose improves mitochondrial respiration by increasing mitochondrial fission through AMPK-Mff signaling; in contrast, supra-pharmacological metformin concentrations reduce mitochondrial respiration through decreasing adenine nucleotide levels.
- adenine nucleotides
- insulin resistance
- membrane potential
- mitochondrial respiration/fission
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)