Metformin adjunctive therapy does not improve the sterilizing activity of the first-line antitubercular regimen in mice

Noton K. Dutta, Michael L. Pinn, Petros C. Karakousis

Research output: Contribution to journalArticlepeer-review

Abstract

Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and sterilizing activities of human-like exposures of metformin when given in combination with the first-line regimen against chronic tuberculosis in BALB/c mice. Mice receiving metformin adjunctive therapy had similar lung bacillary burdens with control mice during treatment, and the proportion of mice with microbiological relapse was similar between the two groups.

Original languageEnglish (US)
Article numbere00652
JournalAntimicrobial agents and chemotherapy
Volume61
Issue number8
DOIs
StatePublished - Aug 2017

Keywords

  • BALB/c
  • Bactericidal
  • Cure
  • Denver regimen
  • Host-directed therapy
  • Metformin
  • Mycobacterium tuberculosis
  • Relapse
  • Standard first-line regimen
  • Sterilizing

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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