Abstract
Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.
Original language | English (US) |
---|---|
Pages (from-to) | 159-162 |
Number of pages | 4 |
Journal | Cell Metabolism |
Volume | 21 |
Issue number | 2 |
DOIs |
|
State | Published - Feb 3 2015 |
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology