Metformin action: Concentrations matter

Ling He, Fredric E. Wondisford

Research output: Contribution to journalComment/debatepeer-review


Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalCell Metabolism
Issue number2
StatePublished - Feb 3 2015

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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