Metformin action: Concentrations matter

Ling He; Fredric E. Wondisford

doi:10.1016/j.cmet.2015.01.003

Metformin action: Concentrations matter

Ling He, Fredric E. Wondisford

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

193 Scopus citations

Abstract

Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.

Original language	English (US)
Pages (from-to)	159-162
Number of pages	4
Journal	Cell Metabolism
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2015.01.003
State	Published - Feb 3 2015

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

Access to Document

10.1016/j.cmet.2015.01.003

Cite this

@article{09d7c731450b4444907b24685fa8b705,

title = "Metformin action: Concentrations matter",

abstract = "Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.",

author = "Ling He and Wondisford, {Fredric E.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = feb,

day = "3",

doi = "10.1016/j.cmet.2015.01.003",

language = "English (US)",

volume = "21",

pages = "159--162",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "2",

}

TY - JOUR

T1 - Metformin action

T2 - Concentrations matter

AU - He, Ling

AU - Wondisford, Fredric E.

PY - 2015/2/3

Y1 - 2015/2/3

N2 - Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.

AB - Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.

UR - http://www.scopus.com/inward/record.url?scp=84922844480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922844480&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2015.01.003

DO - 10.1016/j.cmet.2015.01.003

M3 - Comment/debate

C2 - 25651170

AN - SCOPUS:84922844480

SN - 1550-4131

VL - 21

SP - 159

EP - 162

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

Metformin action: Concentrations matter

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this