Metastatic urachal carcinoma in bronchial brush cytology

Fatima Zahra Aly, Abeer Z. Tabbarah, Lysandra Voltaggio

Research output: Contribution to journalArticle

Abstract

Urachal carcinoma is rare comprising less than 1% of all bladder carcinomas. Metastases of urachal carcinoma have been reported to meninges, brain, ovary, lung, and maxilla. Cytologic features of metastatic urachal carcinoma have not been previously reported. We present a case of metastatic urachal adenocarcinoma in bronchial brushings and review the use of immunohistochemistry in its diagnosis. A 47-year-old female was seen initially in 2007 with adenocarcinoma of the bladder dome for which she underwent partial cystectomy. She presented in 2011 with a left lung mass and mediastinal adenopathy. Bronchoscopy showed an endobronchial lesion from which brushings were obtained. These showed numerous groups of columnar cells with medium sized nuclei and abundant cytoplasm. The cells were positive for CK20 and CDX2 and negative for CK7. The cytomorphological findings were similar to those in the previous resection specimen and concurrent biopsy. This is the first case report of bronchial brushings containing metastatic urachal carcinoma. No specific immunohistochemical profile is available for its diagnosis. The consideration of a second primary was a distinct possibility in this case due to the lapse of time from primary resection, absence of local disease, and lack of regional metastases.

Original languageEnglish (US)
Article number1
JournalCytoJournal
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

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Cell Biology
Urinary Bladder
Neoplasm Metastasis
Meninges
Lung
Cystectomy
Maxilla
Bronchoscopy
Ovary
Cytoplasm
Adenocarcinoma
Immunohistochemistry
Carcinoma
Biopsy
Urachal cancer
Brain

Keywords

  • Bronchial brushings
  • Cytology
  • Immunohistochemistry
  • Metastasis
  • Urachal carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Metastatic urachal carcinoma in bronchial brush cytology. / Aly, Fatima Zahra; Tabbarah, Abeer Z.; Voltaggio, Lysandra.

In: CytoJournal, Vol. 10, No. 1, 1, 01.01.2013.

Research output: Contribution to journalArticle

Aly, Fatima Zahra ; Tabbarah, Abeer Z. ; Voltaggio, Lysandra. / Metastatic urachal carcinoma in bronchial brush cytology. In: CytoJournal. 2013 ; Vol. 10, No. 1.
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