Metastatic pattern of malignant melanoma. A study of 216 autopsy cases

J. K. Patel, M. S. Didolkar, J. W. Pickren, R. H. Moore

Research output: Contribution to journalArticle

Abstract

The metastatic pattern and causes of death were analyzed by autopsy of 216 patients with histologically proven advanced malignant melanoma. These cases constituted 3 per cent of all the autopsies done for cancers from 1959 to 1954 at Roswell Park Memorial Institute, Age range was from six to eighty-six years, with a median value of 49.5 years. Male to female ratio was 1.5:1. Multiple organ metastases were present in 95 per cent of the patients. The most common organs involved were lymph nodes (73.6 per cent), lungs (71.3 per cent), liver (58.3 per cent), brain (49.1 per cent), bone (48.6 per cent), heart (47.2 per cent), adrenal glands (46.8 per cent), and gastrointestinal tract (43.5 per cent). Single organ metastasis was extremely uncommon in malignant melanoma of cutaneous origin. The incidence of histologically different, second primary cancer was 7.4 per cent. The most common cause of death was respiratory failure because of massive involvement of lungs in addition to pleura. The second leading cause of death was complications of brain metastases (increased intracranial pressure and hemorrhage). The median survival was twenty-four months. It appears that this is a selected group of patients with a worse prognosis than expected overall.

Original languageEnglish (US)
Pages (from-to)807-810
Number of pages4
JournalAmerican Journal of Surgery
Volume135
Issue number6
DOIs
StatePublished - 1978
Externally publishedYes

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Cause of Death
Autopsy
Melanoma
Neoplasm Metastasis
Lung
Second Primary Neoplasms
Pleura
Intracranial Hemorrhages
Intracranial Pressure
Brain
Adrenal Glands
Respiratory Insufficiency
Gastrointestinal Tract
Lymph Nodes
Bone and Bones
Survival
Liver
Incidence
Neoplasms
Cutaneous Malignant Melanoma

ASJC Scopus subject areas

  • Surgery

Cite this

Metastatic pattern of malignant melanoma. A study of 216 autopsy cases. / Patel, J. K.; Didolkar, M. S.; Pickren, J. W.; Moore, R. H.

In: American Journal of Surgery, Vol. 135, No. 6, 1978, p. 807-810.

Research output: Contribution to journalArticle

Patel, J. K. ; Didolkar, M. S. ; Pickren, J. W. ; Moore, R. H. / Metastatic pattern of malignant melanoma. A study of 216 autopsy cases. In: American Journal of Surgery. 1978 ; Vol. 135, No. 6. pp. 807-810.
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