Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations

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Gliosarcoma is a rare variant of glioblastoma multiforme characterized by a biphasic pattern of glial and mesenchymal differentiation. Fine-needle aspiration (FNA) is routinely employed to diagnose a number of primary and secondary malignancies in a variety of clinical settings. Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass. The cytologic smears displayed a pleomorphic tumor comprised of spindled and epithelioid malignant cells. This case illustrates the ability of FNA to adequately diagnose a rare malignancy in the appropriate clinico-radiologic setting.

Original languageEnglish (US)
JournalActa Cytologica
StateAccepted/In press - Sep 2 2016


  • Cytopathology
  • Extracranial metastasis
  • Fine-needle aspiration
  • Glioblastoma multiforme
  • Gliosarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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