Metastatic carcinomas from occult primary tumors

A study of 254 patients

M. S. Didolkar, N. Fanous, E. G. Elias, R. H. Moore

Research output: Contribution to journalArticle

Abstract

From 1950 to 1973, 254 patients with metastatic cancers from occult primary tumors, comprising 0.5% of all the referred cancer patients were seen. The average age was 59 years. Clinical presentation was commonly in the form of metastatic lesions in lung, cervical lymph node, bone or liver. Radiological and radioisotopic investigations proved helpful in determining the extent of disease rather than the origin of primary tumor. Adenocarcinoma was the commonest type, followed by undifferentiated and squamous cell carcinomas. The origin of the primary tumor was established in 77 (30%) patients, mostly at autopsy. It was in the lung in 40% of the cases, followed by stomach, pancreas, kidney, ovary and colon. Some correlation was found between clinical presentation and the origin of the primary tumor. Histologically different second cancers were detected in 28 (11%) patients. Overall median and five-year survival rates were nine months and nine per cent respectively. Longer survival was seen in patients with squamous cell carcinoma metastases, middle and upper neck lymph node lesions, and those who had 'curative' surgery. In localized metastatic lesions, surgical extirpation should be done. Depending on the histological type of the metastatic lesions, chemotherapy and/or radiation therapy have definite roles in the management of these patients. Periodic follow-up examinations also prove valuable.

Original languageEnglish (US)
Pages (from-to)625-630
Number of pages6
JournalAnnals of Surgery
Volume186
Issue number5
StatePublished - 1977
Externally publishedYes

Fingerprint

Carcinoma
Neoplasms
Squamous Cell Carcinoma
Lymph Nodes
Lung
Second Primary Neoplasms
Pancreas
Ovary
Autopsy
Stomach
Colon
Adenocarcinoma
Neck
Radiotherapy
Survival Rate
Neoplasm Metastasis
Kidney
Bone and Bones
Drug Therapy
Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Didolkar, M. S., Fanous, N., Elias, E. G., & Moore, R. H. (1977). Metastatic carcinomas from occult primary tumors: A study of 254 patients. Annals of Surgery, 186(5), 625-630.

Metastatic carcinomas from occult primary tumors : A study of 254 patients. / Didolkar, M. S.; Fanous, N.; Elias, E. G.; Moore, R. H.

In: Annals of Surgery, Vol. 186, No. 5, 1977, p. 625-630.

Research output: Contribution to journalArticle

Didolkar, MS, Fanous, N, Elias, EG & Moore, RH 1977, 'Metastatic carcinomas from occult primary tumors: A study of 254 patients', Annals of Surgery, vol. 186, no. 5, pp. 625-630.
Didolkar MS, Fanous N, Elias EG, Moore RH. Metastatic carcinomas from occult primary tumors: A study of 254 patients. Annals of Surgery. 1977;186(5):625-630.
Didolkar, M. S. ; Fanous, N. ; Elias, E. G. ; Moore, R. H. / Metastatic carcinomas from occult primary tumors : A study of 254 patients. In: Annals of Surgery. 1977 ; Vol. 186, No. 5. pp. 625-630.
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