Metastatic bronchioloalveolar carcinoma presenting as a solitary thyroid nodule: Report of a case with fine-needle aspiration cytopathology

Anil V. Parwani, Yener S. Erozan, Syed Z. Ali

Research output: Contribution to journalArticlepeer-review

Abstract

Although cancers metastatic to the thyroid are frequently mentioned in autopsy studies, such a finding is quite rare in routine clinical practice. Metastatic non-small-cell carcinomas to the thyroid may present a diagnostic dilemma, particularly when they share morphological similarities with primary thyroid tumors. Herein, we report a case of metastatic bronchioloalveolar carcinoma that presented as an isolated left thyroid nodule in a 68-year-old woman. The aspirates were cellular and showed numerous papillary-like tissue fragments, elongated nuclei with prominent nuclear grooves, frequent mitoses, and psammoma bodies. The latter features raised the possibility of papillary thyroid carcinoma. However, also seen were three-dimensional tumor nests and acinar-forming fragments. Immunostains (positive for cytokeratin-7 and carcinoembryonic antigen and negative for cytokeratin-20 and thyroglobulin) confirmed the metastatic nature of the carcinoma. In a patient with known primary neoplasm, the differential diagnosis of a thyroid nodule should always include a metastatic lesion along with primary neoplasia.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalDiagnostic cytopathology
Volume31
Issue number1
DOIs
StatePublished - Jul 1 2004

Keywords

  • Bronchioloalveolar carcinoma
  • Lung
  • Metastasis
  • Papillary thyroid carcinoma
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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