Metastatic breast carcinoma presenting as a large pulmonary embolus: Case report and review of the literature

Jean Francois H Geschwind, Mandeep S. Dagli, Jens Vogel-Claussen, Eric Seifter, Michael S. Huncharek

Research output: Contribution to journalArticle

Abstract

Involvement of the pulmonary vasculature by carcinoma of the breast typically occurs in the form of microscopic tumor emboli involving the small arteries, arterioles, or capillaries. Obstruction of a large pulmonary artery by a tumor embolus has not been reported. We describe a patient with a history of breast carcinoma diagnosed 5 years previously who sought treatment for dyspnea and a large mass in the right pulmonary artery suggestive of a pulmonary embolus. After failure of both systemic and intraarterial thrombolytic therapy, a biopsy of the mass was obtained, which revealed adenocarcinoma of the breast. Systemic chemotherapy with doxorubicin and cyclophosphamide was initiated and resulted in the complete resolution of her symptoms.

Original languageEnglish (US)
Pages (from-to)89-91
Number of pages3
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume26
Issue number1
DOIs
StatePublished - Feb 2003

Fingerprint

Embolism
Breast Neoplasms
Lung
Pulmonary Artery
Thrombolytic Therapy
Arterioles
Dyspnea
Doxorubicin
Cyclophosphamide
Neoplasms
Adenocarcinoma
Breast
Arteries
Biopsy
Drug Therapy
Therapeutics

Keywords

  • Breast cancer
  • Endovascular biopsy
  • Metastases
  • Pulmonary embolus
  • Tumor embolus

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Metastatic breast carcinoma presenting as a large pulmonary embolus : Case report and review of the literature. / Geschwind, Jean Francois H; Dagli, Mandeep S.; Vogel-Claussen, Jens; Seifter, Eric; Huncharek, Michael S.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 26, No. 1, 02.2003, p. 89-91.

Research output: Contribution to journalArticle

Geschwind, Jean Francois H ; Dagli, Mandeep S. ; Vogel-Claussen, Jens ; Seifter, Eric ; Huncharek, Michael S. / Metastatic breast carcinoma presenting as a large pulmonary embolus : Case report and review of the literature. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 2003 ; Vol. 26, No. 1. pp. 89-91.
@article{373fe67753e54ef68a22ba44dbe89d71,
title = "Metastatic breast carcinoma presenting as a large pulmonary embolus: Case report and review of the literature",
abstract = "Involvement of the pulmonary vasculature by carcinoma of the breast typically occurs in the form of microscopic tumor emboli involving the small arteries, arterioles, or capillaries. Obstruction of a large pulmonary artery by a tumor embolus has not been reported. We describe a patient with a history of breast carcinoma diagnosed 5 years previously who sought treatment for dyspnea and a large mass in the right pulmonary artery suggestive of a pulmonary embolus. After failure of both systemic and intraarterial thrombolytic therapy, a biopsy of the mass was obtained, which revealed adenocarcinoma of the breast. Systemic chemotherapy with doxorubicin and cyclophosphamide was initiated and resulted in the complete resolution of her symptoms.",
keywords = "Breast cancer, Endovascular biopsy, Metastases, Pulmonary embolus, Tumor embolus",
author = "Geschwind, {Jean Francois H} and Dagli, {Mandeep S.} and Jens Vogel-Claussen and Eric Seifter and Huncharek, {Michael S.}",
year = "2003",
month = "2",
doi = "10.1097/00000421-200302000-00017",
language = "English (US)",
volume = "26",
pages = "89--91",
journal = "American Journal of Clinical Oncology",
issn = "0277-3732",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Metastatic breast carcinoma presenting as a large pulmonary embolus

T2 - Case report and review of the literature

AU - Geschwind, Jean Francois H

AU - Dagli, Mandeep S.

AU - Vogel-Claussen, Jens

AU - Seifter, Eric

AU - Huncharek, Michael S.

PY - 2003/2

Y1 - 2003/2

N2 - Involvement of the pulmonary vasculature by carcinoma of the breast typically occurs in the form of microscopic tumor emboli involving the small arteries, arterioles, or capillaries. Obstruction of a large pulmonary artery by a tumor embolus has not been reported. We describe a patient with a history of breast carcinoma diagnosed 5 years previously who sought treatment for dyspnea and a large mass in the right pulmonary artery suggestive of a pulmonary embolus. After failure of both systemic and intraarterial thrombolytic therapy, a biopsy of the mass was obtained, which revealed adenocarcinoma of the breast. Systemic chemotherapy with doxorubicin and cyclophosphamide was initiated and resulted in the complete resolution of her symptoms.

AB - Involvement of the pulmonary vasculature by carcinoma of the breast typically occurs in the form of microscopic tumor emboli involving the small arteries, arterioles, or capillaries. Obstruction of a large pulmonary artery by a tumor embolus has not been reported. We describe a patient with a history of breast carcinoma diagnosed 5 years previously who sought treatment for dyspnea and a large mass in the right pulmonary artery suggestive of a pulmonary embolus. After failure of both systemic and intraarterial thrombolytic therapy, a biopsy of the mass was obtained, which revealed adenocarcinoma of the breast. Systemic chemotherapy with doxorubicin and cyclophosphamide was initiated and resulted in the complete resolution of her symptoms.

KW - Breast cancer

KW - Endovascular biopsy

KW - Metastases

KW - Pulmonary embolus

KW - Tumor embolus

UR - http://www.scopus.com/inward/record.url?scp=0037318913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037318913&partnerID=8YFLogxK

U2 - 10.1097/00000421-200302000-00017

DO - 10.1097/00000421-200302000-00017

M3 - Article

C2 - 12576931

AN - SCOPUS:0037318913

VL - 26

SP - 89

EP - 91

JO - American Journal of Clinical Oncology

JF - American Journal of Clinical Oncology

SN - 0277-3732

IS - 1

ER -