Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Andrew J. Ewald

doi:10.15252/embj.201899144

Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Andrew J. Ewald

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.

Original language	English (US)
Article number	e99144
Journal	EMBO Journal
Volume	37
Issue number	7
DOIs	https://doi.org/10.15252/embj.201899144
State	Published - Apr 3 2018

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.15252/embj.201899144

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title = "Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity",

abstract = "Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.",

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AB - Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.

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Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Abstract

ASJC Scopus subject areas

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