Metaplastic Squamous Epithelial Downgrowth After Clear Corneal Cataract Surgery

Donald U. Stone; Devron H. Char; J. Brooks Crawford; Todd P. Margolis; Russell N. Van Gelder; Erich C. Strauss

doi:10.1016/j.ajo.2006.04.044

Metaplastic Squamous Epithelial Downgrowth After Clear Corneal Cataract Surgery

Donald U. Stone, Devron H. Char, J. Brooks Crawford, Todd P. Margolis, Russell N. Van Gelder, Erich C. Strauss

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To report a case of metaplastic squamous epithelial downgrowth after cataract surgery. Design: Interventional case report. Methods: Clinical, laboratory, and histologic findings are presented. Our study is in compliance with institutional review board guidelines. Results: A 76-year-old man developed anterior chamber inflammation five months after uncomplicated clear corneal cataract surgery. Despite antimicrobial and anti-inflammatory therapies, the inflammation persisted. An extensive examination failed to demonstrate an infectious etiology or lymphoma. Subsequently, the patient developed an incipient limbal lesion and iris mass. Immunostaining of a biopsy specimen from the iris mass indicated an epithelial-derived tumor. The prephthisical and painful eye was enucleated; histopathology of the globe revealed a contiguous lesion extending from the limbal mass to the iris tumor through the surgical incision site, a finding consistent with metaplastic squamous epithelial downgrowth. Systemic evaluation was negative. Conclusions: After intraocular surgery, metaplastic epithelial downgrowth may occur as a consequence of occult ocular surface squamous neoplasia and masquerade as chronic inflammation; clinicians should be aware of this rare complication.

Original language	English (US)
Pages (from-to)	695-697
Number of pages	3
Journal	American journal of ophthalmology
Volume	142
Issue number	4
DOIs	https://doi.org/10.1016/j.ajo.2006.04.044
State	Published - Oct 2006

ASJC Scopus subject areas

Ophthalmology

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title = "Metaplastic Squamous Epithelial Downgrowth After Clear Corneal Cataract Surgery",

abstract = "Purpose: To report a case of metaplastic squamous epithelial downgrowth after cataract surgery. Design: Interventional case report. Methods: Clinical, laboratory, and histologic findings are presented. Our study is in compliance with institutional review board guidelines. Results: A 76-year-old man developed anterior chamber inflammation five months after uncomplicated clear corneal cataract surgery. Despite antimicrobial and anti-inflammatory therapies, the inflammation persisted. An extensive examination failed to demonstrate an infectious etiology or lymphoma. Subsequently, the patient developed an incipient limbal lesion and iris mass. Immunostaining of a biopsy specimen from the iris mass indicated an epithelial-derived tumor. The prephthisical and painful eye was enucleated; histopathology of the globe revealed a contiguous lesion extending from the limbal mass to the iris tumor through the surgical incision site, a finding consistent with metaplastic squamous epithelial downgrowth. Systemic evaluation was negative. Conclusions: After intraocular surgery, metaplastic epithelial downgrowth may occur as a consequence of occult ocular surface squamous neoplasia and masquerade as chronic inflammation; clinicians should be aware of this rare complication.",

author = "Stone, {Donald U.} and Char, {Devron H.} and Crawford, {J. Brooks} and Margolis, {Todd P.} and {Van Gelder}, {Russell N.} and Strauss, {Erich C.}",

year = "2006",

month = oct,

doi = "10.1016/j.ajo.2006.04.044",

language = "English (US)",

volume = "142",

pages = "695--697",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

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AU - Stone, Donald U.

AU - Char, Devron H.

AU - Crawford, J. Brooks

AU - Margolis, Todd P.

AU - Van Gelder, Russell N.

AU - Strauss, Erich C.

PY - 2006/10

Y1 - 2006/10

N2 - Purpose: To report a case of metaplastic squamous epithelial downgrowth after cataract surgery. Design: Interventional case report. Methods: Clinical, laboratory, and histologic findings are presented. Our study is in compliance with institutional review board guidelines. Results: A 76-year-old man developed anterior chamber inflammation five months after uncomplicated clear corneal cataract surgery. Despite antimicrobial and anti-inflammatory therapies, the inflammation persisted. An extensive examination failed to demonstrate an infectious etiology or lymphoma. Subsequently, the patient developed an incipient limbal lesion and iris mass. Immunostaining of a biopsy specimen from the iris mass indicated an epithelial-derived tumor. The prephthisical and painful eye was enucleated; histopathology of the globe revealed a contiguous lesion extending from the limbal mass to the iris tumor through the surgical incision site, a finding consistent with metaplastic squamous epithelial downgrowth. Systemic evaluation was negative. Conclusions: After intraocular surgery, metaplastic epithelial downgrowth may occur as a consequence of occult ocular surface squamous neoplasia and masquerade as chronic inflammation; clinicians should be aware of this rare complication.

AB - Purpose: To report a case of metaplastic squamous epithelial downgrowth after cataract surgery. Design: Interventional case report. Methods: Clinical, laboratory, and histologic findings are presented. Our study is in compliance with institutional review board guidelines. Results: A 76-year-old man developed anterior chamber inflammation five months after uncomplicated clear corneal cataract surgery. Despite antimicrobial and anti-inflammatory therapies, the inflammation persisted. An extensive examination failed to demonstrate an infectious etiology or lymphoma. Subsequently, the patient developed an incipient limbal lesion and iris mass. Immunostaining of a biopsy specimen from the iris mass indicated an epithelial-derived tumor. The prephthisical and painful eye was enucleated; histopathology of the globe revealed a contiguous lesion extending from the limbal mass to the iris tumor through the surgical incision site, a finding consistent with metaplastic squamous epithelial downgrowth. Systemic evaluation was negative. Conclusions: After intraocular surgery, metaplastic epithelial downgrowth may occur as a consequence of occult ocular surface squamous neoplasia and masquerade as chronic inflammation; clinicians should be aware of this rare complication.

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Metaplastic Squamous Epithelial Downgrowth After Clear Corneal Cataract Surgery

Abstract

ASJC Scopus subject areas

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