Metalloproteomics: Challenges and prospective for clinical research applications

Dax Fu, Lydia Finney

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Metals are essential cofactors, utilized in many critical cellular processes. For example, zinc is important in insulin biosynthesis and may play a role in Alzheimer's disease, but much of how the zinc-mediated process remains unknown. Knowing which metal is in which protein at a given point in time would lead to new insights into how metals work in biological systems. New tools are being developed to investigate the biochemistry and cell biology of metals, with potential for biomedical applications. In this report, we consider the promise and limitations of metalloproteins detection techniques. We provide a brief overview of the techniques available and a discussion of the technical challenges to biomedical applications, with particular focus on what must be overcome for the potential of these approaches to be achieved.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalExpert Review of Proteomics
Volume11
Issue number1
DOIs
StatePublished - Feb 2014

Keywords

  • elemental analysis
  • metalloproteins
  • metalloproteomics
  • metals
  • molecular pathology

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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