Metallic wear debris from periprosthetic tissue of failed arthroplasty induces TNFα and IL-1α release from synoviocytes

S. P. Bendall; A. J. Radfar; C. Frondoza; R. H. Jinnah; D. S. Hungerford

Metallic wear debris from periprosthetic tissue of failed arthroplasty induces TNFα and IL-1α release from synoviocytes

S. P. Bendall, A. J. Radfar, C. Frondoza, R. H. Jinnah, D. S. Hungerford

School of Medicine

Research output: Contribution to conference › Paper › peer-review

2 Scopus citations

Abstract

The effects of metallic wear debris on the performance of surgical implants and joint prostheses were investigated through in vitro experiments. Periprosthetic tissues were obtained from failed cobalt-chrome-molybdenum hip and TiAlV failed prostheses during replacement surgery and characterized by scanning electron microscopy (SEM). Results suggest that metallic wear debris is cytotoxic to human synoviocytes with release of inflammatory cytokines.

Original language	English (US)
Number of pages	1
State	Published - Dec 1 1996
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

Other

Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

General Materials Science

Cite this

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title = "Metallic wear debris from periprosthetic tissue of failed arthroplasty induces TNFα and IL-1α release from synoviocytes",

abstract = "The effects of metallic wear debris on the performance of surgical implants and joint prostheses were investigated through in vitro experiments. Periprosthetic tissues were obtained from failed cobalt-chrome-molybdenum hip and TiAlV failed prostheses during replacement surgery and characterized by scanning electron microscopy (SEM). Results suggest that metallic wear debris is cytotoxic to human synoviocytes with release of inflammatory cytokines.",

author = "Bendall, {S. P.} and Radfar, {A. J.} and C. Frondoza and Jinnah, {R. H.} and Hungerford, {D. S.}",

year = "1996",

month = dec,

day = "1",

language = "English (US)",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

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TY - CONF

T1 - Metallic wear debris from periprosthetic tissue of failed arthroplasty induces TNFα and IL-1α release from synoviocytes

AU - Bendall, S. P.

AU - Radfar, A. J.

AU - Frondoza, C.

AU - Jinnah, R. H.

AU - Hungerford, D. S.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - The effects of metallic wear debris on the performance of surgical implants and joint prostheses were investigated through in vitro experiments. Periprosthetic tissues were obtained from failed cobalt-chrome-molybdenum hip and TiAlV failed prostheses during replacement surgery and characterized by scanning electron microscopy (SEM). Results suggest that metallic wear debris is cytotoxic to human synoviocytes with release of inflammatory cytokines.

AB - The effects of metallic wear debris on the performance of surgical implants and joint prostheses were investigated through in vitro experiments. Periprosthetic tissues were obtained from failed cobalt-chrome-molybdenum hip and TiAlV failed prostheses during replacement surgery and characterized by scanning electron microscopy (SEM). Results suggest that metallic wear debris is cytotoxic to human synoviocytes with release of inflammatory cytokines.

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M3 - Paper

AN - SCOPUS:0030382712

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Metallic wear debris from periprosthetic tissue of failed arthroplasty induces TNFα and IL-1α release from synoviocytes

Abstract

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ASJC Scopus subject areas

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