Metallic wear debris from periprosthetic tissue of failed arthroplasty induces TNFα and IL-1α release from synoviocytes

S. P. Bendall, A. J. Radfar, C. Frondoza, R. H. Jinnah, D. S. Hungerford

Research output: Contribution to conferencePaper

Abstract

The effects of metallic wear debris on the performance of surgical implants and joint prostheses were investigated through in vitro experiments. Periprosthetic tissues were obtained from failed cobalt-chrome-molybdenum hip and TiAlV failed prostheses during replacement surgery and characterized by scanning electron microscopy (SEM). Results suggest that metallic wear debris is cytotoxic to human synoviocytes with release of inflammatory cytokines.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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    Bendall, S. P., Radfar, A. J., Frondoza, C., Jinnah, R. H., & Hungerford, D. S. (1996). Metallic wear debris from periprosthetic tissue of failed arthroplasty induces TNFα and IL-1α release from synoviocytes. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .