Metal ions and RNA folding: A highly charged topic with a dynamic future

Sarah A. Woodson

Research output: Contribution to journalReview article

Abstract

Metal ions are required to stabilize RNA tertiary structure and to begin the folding process. How different metal ions enable RNAs to fold depends on the electrostatic potential of the RNA and correlated fluctuations in the positions of the ions themselves. Theoretical models, fluorescence spectroscopy, small angle scattering and structural biology reveal that metal ions alter the RNA dynamics and folding transition states. Specifically coordinated divalent metal ions mediate conformational rearrangements within ribozyme active sites.

Original languageEnglish (US)
Pages (from-to)104-109
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume9
Issue number2
DOIs
StatePublished - Apr 2005

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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