Metagenomics: A newway to illustrate the crosstalk between infectious diseases and host microbiome

Yinfeng Zhang, Cheuk Yin Lun, Stephen Kwok Wing Tsui

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Microbes have co-evolved with human beings for millions of years. They play a very important role in maintaining the health of the host. With the advancement in next generation sequencing technology, the microbiome profiling in the host can be obtained under different circumstances. This review focuses on the current knowledge of the alteration of complex microbial communities upon the infection of different pathogens, such as human immunodeficiency virus, hepatitis B virus, influenza virus, and Mycobacterium tuberculosis, at different body sites. It is believed that the increased understanding of the correlation between infectious disease and the alteration of the microbiome can contribute to better management of disease progression in the future. However, future studies may need to be more integrative so as to establish the exact causality of diseases by analyzing the correlation between microorganisms within the human host and the pathogenesis of infectious diseases.

Original languageEnglish (US)
Pages (from-to)26263-26279
Number of pages17
JournalInternational journal of molecular sciences
Issue number11
StatePublished - Nov 3 2015
Externally publishedYes


  • HBV
  • HIV
  • Infectious disease
  • Influenza
  • Metagenomics
  • Microbiome
  • Next generation sequencing
  • Tuberculosis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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