Metagenomic Approaches for Defining the Pathogenesis of Inflammatory Bowel Diseases

Daniel A. Peterson, Daniel N. Frank, Norman R. Pace, Jeffrey I. Gordon

Research output: Contribution to journalArticle

Abstract

The human gastrointestinal tract is home to immense and complex populations of microorganisms. Using recent technical innovations, the diversity present in this human body habitat is now being analyzed in detail. This review focuses on the microbial ecology of the gut in inflammatory bowel diseases and on how recent studies provide an impetus for using carefully designed, comparative metagenomic approaches to delve into the structure and activities of the gut microbial community and its interrelationship with the immune system.

Original languageEnglish (US)
Pages (from-to)417-427
Number of pages11
JournalCell Host and Microbe
Volume3
Issue number6
DOIs
StatePublished - Jun 12 2008
Externally publishedYes

Fingerprint

Metagenomics
Ecology
Inflammatory Bowel Diseases
Human Body
Ecosystem
Gastrointestinal Tract
Immune System
Population

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

Metagenomic Approaches for Defining the Pathogenesis of Inflammatory Bowel Diseases. / Peterson, Daniel A.; Frank, Daniel N.; Pace, Norman R.; Gordon, Jeffrey I.

In: Cell Host and Microbe, Vol. 3, No. 6, 12.06.2008, p. 417-427.

Research output: Contribution to journalArticle

Peterson, Daniel A. ; Frank, Daniel N. ; Pace, Norman R. ; Gordon, Jeffrey I. / Metagenomic Approaches for Defining the Pathogenesis of Inflammatory Bowel Diseases. In: Cell Host and Microbe. 2008 ; Vol. 3, No. 6. pp. 417-427.
@article{9e0546c0fe404403bbbf469e2dfa5c14,
title = "Metagenomic Approaches for Defining the Pathogenesis of Inflammatory Bowel Diseases",
abstract = "The human gastrointestinal tract is home to immense and complex populations of microorganisms. Using recent technical innovations, the diversity present in this human body habitat is now being analyzed in detail. This review focuses on the microbial ecology of the gut in inflammatory bowel diseases and on how recent studies provide an impetus for using carefully designed, comparative metagenomic approaches to delve into the structure and activities of the gut microbial community and its interrelationship with the immune system.",
author = "Peterson, {Daniel A.} and Frank, {Daniel N.} and Pace, {Norman R.} and Gordon, {Jeffrey I.}",
year = "2008",
month = "6",
day = "12",
doi = "10.1016/j.chom.2008.05.001",
language = "English (US)",
volume = "3",
pages = "417--427",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Metagenomic Approaches for Defining the Pathogenesis of Inflammatory Bowel Diseases

AU - Peterson, Daniel A.

AU - Frank, Daniel N.

AU - Pace, Norman R.

AU - Gordon, Jeffrey I.

PY - 2008/6/12

Y1 - 2008/6/12

N2 - The human gastrointestinal tract is home to immense and complex populations of microorganisms. Using recent technical innovations, the diversity present in this human body habitat is now being analyzed in detail. This review focuses on the microbial ecology of the gut in inflammatory bowel diseases and on how recent studies provide an impetus for using carefully designed, comparative metagenomic approaches to delve into the structure and activities of the gut microbial community and its interrelationship with the immune system.

AB - The human gastrointestinal tract is home to immense and complex populations of microorganisms. Using recent technical innovations, the diversity present in this human body habitat is now being analyzed in detail. This review focuses on the microbial ecology of the gut in inflammatory bowel diseases and on how recent studies provide an impetus for using carefully designed, comparative metagenomic approaches to delve into the structure and activities of the gut microbial community and its interrelationship with the immune system.

UR - http://www.scopus.com/inward/record.url?scp=44649118583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44649118583&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2008.05.001

DO - 10.1016/j.chom.2008.05.001

M3 - Article

C2 - 18541218

AN - SCOPUS:44649118583

VL - 3

SP - 417

EP - 427

JO - Cell Host and Microbe

JF - Cell Host and Microbe

SN - 1931-3128

IS - 6

ER -