Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo

G. Riedel, D. Manahan-Vaughan, A. P. Kozikowski, K. G. Reymann

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the role of metabotropic glutamate receptors by studying the effect of intracerebroventricular infusion of the putative mGluR agonist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potentiation (LTP) in the dentate gyrus of freely moving rats. Weak tetanization caused a decremental potentiation which returned to baseline levels within 2 hr. Injections of tADA (20 mM/5 μ1) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.

Original languageEnglish (US)
Pages (from-to)1107-1109
Number of pages3
JournalNeuropharmacology
Volume34
Issue number8
DOIs
StatePublished - Aug 1995

Keywords

  • 4-dicarboxylic acid (tADA)
  • Long-term potentiation (LTP)
  • Metabotropic glutamate receptors (mGluRs)
  • Trans-azetidine-2

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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