Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo

G. Riedel; D. Manahan-Vaughan; A. P. Kozikowski; K. G. Reymann

doi:10.1016/0028-3908(95)00110-R

Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo

G. Riedel, D. Manahan-Vaughan, A. P. Kozikowski, K. G. Reymann

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We examined the role of metabotropic glutamate receptors by studying the effect of intracerebroventricular infusion of the putative mGluR agonist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potentiation (LTP) in the dentate gyrus of freely moving rats. Weak tetanization caused a decremental potentiation which returned to baseline levels within 2 hr. Injections of tADA (20 mM/5 μ1) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.

Original language	English (US)
Pages (from-to)	1107-1109
Number of pages	3
Journal	Neuropharmacology
Volume	34
Issue number	8
DOIs	https://doi.org/10.1016/0028-3908(95)00110-R
State	Published - Aug 1995

Keywords

4-dicarboxylic acid (tADA)
Long-term potentiation (LTP)
Metabotropic glutamate receptors (mGluRs)
Trans-azetidine-2

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(95)00110-R

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title = "Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo",

abstract = "We examined the role of metabotropic glutamate receptors by studying the effect of intracerebroventricular infusion of the putative mGluR agonist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potentiation (LTP) in the dentate gyrus of freely moving rats. Weak tetanization caused a decremental potentiation which returned to baseline levels within 2 hr. Injections of tADA (20 mM/5 μ1) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.",

keywords = "4-dicarboxylic acid (tADA), Long-term potentiation (LTP), Metabotropic glutamate receptors (mGluRs), Trans-azetidine-2",

author = "G. Riedel and D. Manahan-Vaughan and Kozikowski, {A. P.} and Reymann, {K. G.}",

note = "Funding Information: Acknowledgements-The authors are indebted to the expert technical assistenceo f Mrs Silvia Vieweg. This work was supportedb y grants of the European Community (BMHI-CT93-1033)t o KGR and the county stateo f Sachsen-Anhalt (1603A-8324t)o KGR and GR. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1995",

month = aug,

doi = "10.1016/0028-3908(95)00110-R",

language = "English (US)",

volume = "34",

pages = "1107--1109",

journal = "Neuropharmacology",

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T1 - Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo

AU - Riedel, G.

AU - Manahan-Vaughan, D.

AU - Kozikowski, A. P.

AU - Reymann, K. G.

N1 - Funding Information: Acknowledgements-The authors are indebted to the expert technical assistenceo f Mrs Silvia Vieweg. This work was supportedb y grants of the European Community (BMHI-CT93-1033)t o KGR and the county stateo f Sachsen-Anhalt (1603A-8324t)o KGR and GR. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1995/8

Y1 - 1995/8

N2 - We examined the role of metabotropic glutamate receptors by studying the effect of intracerebroventricular infusion of the putative mGluR agonist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potentiation (LTP) in the dentate gyrus of freely moving rats. Weak tetanization caused a decremental potentiation which returned to baseline levels within 2 hr. Injections of tADA (20 mM/5 μ1) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.

AB - We examined the role of metabotropic glutamate receptors by studying the effect of intracerebroventricular infusion of the putative mGluR agonist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potentiation (LTP) in the dentate gyrus of freely moving rats. Weak tetanization caused a decremental potentiation which returned to baseline levels within 2 hr. Injections of tADA (20 mM/5 μ1) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.

KW - 4-dicarboxylic acid (tADA)

KW - Long-term potentiation (LTP)

KW - Metabotropic glutamate receptors (mGluRs)

KW - Trans-azetidine-2

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JO - Neuropharmacology

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Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo

Abstract

Keywords

ASJC Scopus subject areas

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